Scientists test Direct-to-Brain immune therapy in kids with aggressive tumors

This early-phase study tested a personalized cell therapy for children and young adults with recurrent or hard-to-treat brain tumors. Doctors collected patients' own immune cells, engineered them in a lab to target a specific protein (EGFR) on the tumor, and then delivered these 'CAR T cells' directly into the brain fluid via a catheter. The main goals were to see if this approach was safe and feasible, and to monitor how the engineered cells moved within the body.