Cancer drug cabozantinib tested in kids and young adults with bone cancer

NCT ID NCT06341712

Terminated Disease control Sponsor: Ipsen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug cabozantinib in children, teens, and young adults with osteosarcoma (a bone cancer) that could not be fully removed by surgery. Participants who had stable or partially improved disease after chemotherapy received either cabozantinib plus best supportive care or best supportive care alone. The goal was to see if cabozantinib could delay cancer progression. The trial was terminated early and enrolled only 10 people, so its findings are very limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cabozantinib (a cancer drug taken as a tablet)
What this could lead to: If it works, this could offer a way to delay cancer growth in young people with osteosarcoma that cannot be surgically removed.
What could go wrong: This trial was terminated early with only 10 participants, so results are very limited. Cabozantinib may cause side effects like fatigue, diarrhea, or high blood pressure, and it is not a cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteosarcoma pediatric osteosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOSARCOMA OSTEOSARCOMA IN ADOLESCENTS AND YOUNG ADULTS OSTEOSARCOMA IN CHILDREN

Contacts and locations

Locations

AOU Città della Salute e della Scienza di Torino

Piemonte, Italy
Amsterdam UMC - Locatie AMC

Amsterdam, Netherlands
Birmingham Children's Hospital

Birmingham, United Kingdom
Centre Oscar Lambret

Lille, France
Children's Hospital of the King's Daughters

Norfolk, Virginia, 23507, United States
Dr. von Haunerschen Kinderspital

München, Germany
Hospital Infantil Universitario Nino Jesus

Madrid, Spain
Hospital Universitari i Politecnic La Fe

Valencia, Spain
Hospital Universitario Vall d'Hebron

Barcelona, Spain
Hospital de La Santa Creu i Sant Pau

Barcelona, Spain
Instytut Matki i Dziecka

Warsaw, Poland
McGill University Health Centre - Centre for Innovative Medicine

Québec, Canada
Ospedale Ortopedico Rizzoli di Bologna

Bologna, Italy
Princess Margaret cancer center

Toronto, Canada
University Hospital Gent

Ghent, Belgium
Universitätsmedizin Mainz

Mainz, Germany

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