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Could a trace mineral in your saliva signal gum disease?

NCT ID NCT07775378

Knowledge-focused Sponsor: Marmara University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study investigates whether boron levels in saliva and gum tissue are linked to oxidative stress, antioxidant defenses, and inflammation in people with periodontitis (severe gum disease). Researchers will compare samples from 60 systemically healthy, non-smoking adults—half with Stage III-IV periodontitis and half with healthy gums. No treatment is given; the goal is to see if boron levels differ between the groups and correlate with markers of gum inflammation and oxidative damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
No experimental treatment; this is an observational study collecting saliva and gum tissue samples for biochemical analysis.
What this could lead to
If a link is found, boron levels might serve as a marker for periodontal inflammation or oxidative stress, potentially guiding future diagnostic or therapeutic approaches.
What could go wrong
This is a small observational study, so it cannot prove cause and effect. Any findings will need confirmation in larger, more diverse groups.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of 60 systemically healthy individuals aged 18-65 years attending the Department of Periodontology, Faculty of Dentistry, Marmara University. Participants will be divided into two groups: 30 individuals with Stage III-IV periodontitis with an indication for periodontal flap surgery and 30 periodontally healthy individuals with an indication for crown-lengthening surgery.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Volunteering to participate in the study and signing the informed consent form * Being between 18 and 65 years of age * Being systemically healthy * No antibiotic use within the last 3 months * No periodontal treatment within the last 6 months * Being a non-smoker or having quit smoking at least 5 years ago * Not being pregnant or breastfeeding * No current use of steroids, immunosuppressive drugs, or non-steroidal anti-inflammatory drugs * No current use of medications associated with gingival enlargement, such as calcium channel blockers, phenytoin, or cyclosporine * No regular use of boron-containing supplements or multivitamin complexes * For the periodontally healthy group: no clinical attachment loss, bleeding on probing \<10%, probing depth ≤3 mm, no radiographic bone loss, and an indication for crown-lengthening surgery * For the periodontitis group: diagnosis of Stage III or IV periodontitis according to the 2017 World Workshop classification and an indication for periodontal flap surgery Exclusion Criteria: * Incomplete or unreliable clinical measurements * Insufficient saliva or gingival tissue sample for biochemical analyses * Regular use of boron-containing oral care products within the last 3 months * Regular consumption of boron-rich supplements or mineral waters * Failure to comply with the study protocol

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Conditions

The condition(s) this trial relates to.

Inflammation periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • : Department of Periodontology, Faculty of Dentistry, Marmara University, Istanbul,

    RECRUITING

    Istanbul, Maltepe, 34854, Turkey (Türkiye)

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