Could your own bone marrow fix jaw pain? new trial tests it

NCT ID NCT07536399

Recruiting now Disease control Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether injecting a concentrate of your own bone marrow (BMAC) into the jaw joint during arthroscopy reduces pain and damage better than a standard steroid shot. Twenty adults with long-lasting TMJ pain will be randomly assigned to one of the two treatments and followed for 6 months with questionnaires and MRIs. The goal is to see if this natural approach can calm inflammation and improve jaw function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Bone marrow aspirate concentrate (BMAC) and corticosteroid
What this could lead to: If BMAC works better than steroids, it could offer a longer-lasting, natural treatment for TMJ pain and joint damage.
What could go wrong: This is a small, early-phase trial with only 20 people. BMAC is experimental for TMJ, and results may not apply to everyone. Risks include pain or infection from the bone marrow harvest.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ORAL AND MAXILLOFACIAL CONDITIONS TMJ - ORAL &MAXILLOFACIAL SURGERY TMJ ARTHRALGIA TMJ PAIN

Contacts and locations

Locations

Weill Cornell Medical College - NewYork-Presbyterian Hospital
RECRUITING

New York, New York, 10024, United States

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