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Can a brain scan and your phone predict where depression goes next?

NCT ID NCT07033923

NEW Knowledge-focused Sponsor: Centre Hospitalier St Anne Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers want to know whether mathematical models of mood, combined with brain imaging and daily smartphone check-ins, can describe mood in a way that matters for depression and bipolar disorder. The study enrolls three groups of 96 people each: those with depression, those with bipolar disorder, and healthy volunteers. Participants complete a brain MRI session with optional cognitive tests, then rate their mood and daily events on a phone app over time. Two optional add-ons use the app to track emotions passively and to record voice for vocal and language analysis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Brain MRI plus smartphone-based mood tracking and cognitive tests
What this could lead to
If the approach works, doctors might one day use a short brain scan plus daily phone check-ins to predict how someone's depression or bipolar disorder will change over the following months.
What could go wrong
This is an observational study, not a treatment, so it will not cure or ease mood disorders. The models may fail to predict real-life mood changes, and the findings may not apply to everyone with these conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 588 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2024

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Common between groups (DD, BD, control and GP): * Having given informed and written consent * Being covered by social security For patients with depressive disorder (DD): * Having been diagnosed with characterized depressive episode (F32, F33, F34) according to the ICD-10, by a psychiatrist, or having presented this diagnosis during the past 12 months For patients with bipolar disorder (BD): * Presenting a diagnosis of bipolar mood disorder (F31) according to ICD-10, by a psychiatrist * Having presented a mood episode (F31.0 - F31.6) diagnosed during the past 12 months by a psychiatrist Exclusion Criteria: Common between groups (DD, BD, control and GP): * Inability to carry out daily monitoring on mobile application for 12 months * legal protection measure (guardianship or curatorship) For control group: * Current diagnosis of psychiatric disorder in ICD-10 (F20-F98) or prescription of psychotropic treatment * History of depression (F32) * Syndrome of dependence on a psychoactive substance other than tobacco * Neurological history (in particular history of stroke, coma, epilepsy, neuro- inflammatory, or neuro-degenerative disease) * Inability to carry out daily monitoring on mobile application for 12 months For patients and healthy volunteers for whom an MRI (without injection of contrast agent) is proposed * Contraindication to MRI: cardiac pacemaker not compatible with MRI, heart valve implant, implant or metallic foreign body * Pregnant woman (at the time of MRI)

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Conditions

The condition(s) this trial relates to.

bipolar disorder Depression depressive disorder mood disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bipolar disorder Depression Mood disorders Recurrent depression

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • - Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences

    RECRUITING

    Paris, Paris, 75014, France

  • Assistance Publique - Hôpitaux de Paris GH Pitié-Salpêtrière

    RECRUITING

    Paris, 75651, France

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