Massive study aims to unlock genetic secrets of rare liver disease in kids
NCT ID NCT00345553
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is collecting medical information, genetic material, and body fluid samples from over 1,200 children with biliary atresia, a rare liver disease. The goal is to find genes that cause the disease and understand how it progresses in children who still have their own liver. No new treatments are being tested; instead, researchers hope to learn more about the disease to guide future care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify genes linked to biliary atresia and better predict how the disease progresses in children who haven't had a liver transplant.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly improve health. It may take years to yield useful insights, and genetic findings may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60614, United States
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Children's Healthcare of Atlanta - Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Children's Hospital of Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Hospital for Sick Children
COMPLETEDToronto, Ontario, M5G 1X8, Canada
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Johns Hopkins School of Medicine
COMPLETEDBaltimore, Maryland, 21287, United States
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Mount Sinai Medical Center
COMPLETEDNew York, New York, 10029, United States
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Riley Children's Hospital
COMPLETEDIndianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Texas Children's Hospital (Baylor College of Medicine)
RECRUITINGHouston, Texas, 77030, United States
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UPMC Children's Hospital of Pittsburgh
COMPLETEDPittsburgh, Pennsylvania, 15224, United States
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University of California at San Francisco
COMPLETEDSan Francisco, California, 94143, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84113, United States
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Washington University School of Medicine
COMPLETEDSt Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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