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Can beetroot juice shield blood vessels from Vaccine-Related inflammation?

NCT ID NCT04889274

Prevention Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 25, 2026 · Last updated Sep 25, 2026

Summary

Researchers are investigating whether dietary nitrate, found in beetroot juice, can protect blood vessels from inflammation caused by COVID-19 vaccination. The trial enrolls 42 healthy men and women aged 18 to 60 who are scheduled to receive a COVID-19 vaccine. Participants receive either nitrate-rich beetroot juice or a nitrate-depleted version, and researchers measure blood vessel function and markers of inflammation before and after vaccination. The study also compares how men and women respond to the vaccine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Beetroot juice containing dietary nitrate
What this could lead to
If nitrate helps, it could offer a simple dietary way to protect blood vessels from inflammation after vaccination, and clarify whether men and women respond differently.
What could go wrong
This is a small, early-stage study of 42 healthy volunteers. It may not show a clear effect, and results in healthy young adults may not apply to other groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

42 people

The number who actually took part.

Started

May 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Healthy volunteers with a booking for COVID-19 vaccination slot as per government guidelines 2. Aged 18-60 3. Volunteers who are willing to sign the consent form Exclusion Criteria: 1. Aged \<18 or \>60 years 2. Healthy subjects unwilling to consent 3. Pregnant, or any possibility that a subject may be pregnant 4. History of any serious illnesses, including recent infections or trauma 5. Subjects taking systemic medication (other than the oral contraceptive pill) 6. Subjects with self-reported use of mouthwash or tongue scrapes 7. Subjects with recent (2 weeks) or current antibiotic use 8. Subjects with a history, or recent treatment of (within last 3 months) any oral condition (excluding caries), including gingivitis, periodontitis and halitosis 9. Subjects with a history of COVID-19 vaccination 10. Subjects with any history of a blood-borne infectious

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Coitus COVID-19

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Endothelial dysfunction

Contacts and locations

Locations

  • The William Harvey Research Institute

    London, EC1M 6BQ, United Kingdom

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