Friendly bacteria bladder wash aims to stop UTIs without antibiotics

NCT ID NCT04846803

Recruiting now Prevention Sponsor: Odense University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests whether washing the bladder with a harmless strain of E. coli can prevent recurrent urinary tract infections (UTIs) in people who have failed other treatments. Researchers will compare the harmless bacteria wash to a saltwater wash in 80 participants, tracking how many UTIs occur over time. If successful, this could offer an antibiotic-free prevention option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: non-pathogenic E. coli bacteria (ABU strain) for bladder lavage
What this could lead to: If it works, this could offer a new way to prevent recurrent UTIs without antibiotics, reducing the need for frequent medication.
What could go wrong: This is a small, early-stage trial (80 people) testing a novel approach. The bacteria may not outcompete harmful strains in all patients, and long-term effectiveness is unknown.

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Conditions

The condition(s) this trial relates to.

escherichia coli infection urinary tract infection urinary tract infections, recurrent, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT URINARY TRACT INFECTIONS

Contacts and locations

Locations

Aarhus University Hospital
RECRUITING

Aarhus N, 8200, Denmark
Odense University Hospital
RECRUITING

Odense C, 5000, Denmark

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