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Can a weekly shot help tackle obesity in type 2 diabetes?

NCT ID NCT07784270

Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time

Summary

This trial is testing whether an investigational drug called AZD6234, given as a weekly injection, can help adults with type 2 diabetes and excess weight lose more weight than a placebo. Participants will receive either AZD6234 or a placebo for 68 weeks, and researchers will measure changes in body weight. The study aims to see if the drug is effective and safe for this population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AZD6234, an investigational drug given as a weekly injection
What this could lead to
If successful, AZD6234 could offer a new treatment option for weight loss in people with type 2 diabetes, potentially improving blood sugar control and reducing obesity-related health risks.
What could go wrong
This is an early-stage test in a large group, and results may not confirm benefit. Possible side effects and individual responses vary, and the drug may not be approved or widely available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males \& females (inclusive of all gender identities) age ≥18 years * BMI ≥27 kg/m2 * Diagnosed with T2DM ≥90 days prior to Screening * HbA1c value at Screening of ≥6.0% (42 mmol/mol) and ≤10% (86 mmol/mol) managed with diet and exercise alone or with a stable dose of any oral glycaemic-lowering agent (as per local labelling) * Stable body weight (≤5% body weight change) for at least 3 months prior to Randomisation * History of at least one self-reported unsuccessful attempt to lose body weight in lifetime Exclusion Criteria: * Obesity primarily caused by other endocrine disorders * Type 1 diabetes mellitus (or any other diabetes mellitus that is not clearly Type 2 diabetes), OR have history of ketoacidosis or hyperosmolar coma/state within 3 months prior to Screening * Significant hepatobiliary disease and/or any of the following results at Screening: * ALT ≥ 3.0 X ULN * AST ≥ 3.0 X ULN * TBL \> 1.5 X ULN (except for cases of known Gilbert's Syndrome) * Has received treatment with a GLP-1 receptor agonist or GLP-1 containing medication for any indication within 3 months before Randomisation * Use of insulin therapy for T2DM within 3 months prior to screening

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus, type 2 Obesity or overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    218 sites in 16 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Research Site

    Fairhope, Alabama, 36532, United States

  • Research Site

    Huntsville, Alabama, 35801, United States

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    Mesa, Arizona, 85213, United States

  • Research Site

    Phoenix, Arizona, 85044, United States

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    Tucson, Arizona, 85715, United States

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    Little Rock, Arkansas, 72205, United States

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    Bakersfield, California, 93309, United States

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    Gardena, California, 90247, United States

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    Lincoln, California, 95648, United States

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    Torrance, California, 90503, United States

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    Walnut Creek, California, 94598, United States

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    Coral Gables, Florida, 33134, United States

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    Fleming Island, Florida, 32003, United States

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    Fort Lauderdale, Florida, 33316, United States

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    Ocoee, Florida, 34761, United States

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    Woodstock, Georgia, 30189, United States

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    Chicago, Illinois, 60640, United States

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    Melrose Park, Illinois, 60160, United States

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    Lenexa, Kansas, 66219, United States

  • Research Site

    Newton, Kansas, 67114, United States

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    Monroe, Louisiana, 71201, United States

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    Beltsville, Maryland, 20705, United States

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    Lanham, Maryland, 20706, United States

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    Oxon Hill, Maryland, 20745, United States

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    North Dartmouth, Massachusetts, 02747, United States

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    Farmington Hills, Michigan, 48336, United States

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    Fayette, Mississippi, 39069, United States

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    Kansas City, Missouri, 64111, United States

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    St Louis, Missouri, 63141, United States

  • Research Site

    Omaha, Nebraska, 68114, United States

  • Research Site

    Omaha, Nebraska, 68144, United States

  • Research Site

    Eatontown, New Jersey, 07724, United States

  • Research Site

    Somerset, New Jersey, 08873, United States

  • Research Site

    Warren Township, New Jersey, 07059, United States

  • Research Site

    Greensboro, North Carolina, 27408, United States

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    Monroe, North Carolina, 28112, United States

  • Research Site

    Munroe Falls, Ohio, 44262, United States

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    Scottdale, Pennsylvania, 15683, United States

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    Franklin, Tennessee, 37067, United States

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    Knoxville, Tennessee, 37938, United States

  • Research Site

    DeSoto, Texas, 75115, United States

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    El Paso, Texas, 79935, United States

  • Research Site

    Houston, Texas, 77099, United States

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    Midland, Texas, 79707, United States

  • Research Site

    Pasadena, Texas, 77504, United States

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    San Antonio, Texas, 78207, United States

  • Research Site

    San Antonio, Texas, 78215, United States

  • Research Site

    San Antonio, Texas, 78251, United States

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    Manassas, Virginia, 20110, United States

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    Norfolk, Virginia, 23504, United States

  • Research Site

    CABA, C1120AAC, Argentina

  • Research Site

    CABA, C1425HFA, Argentina

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    Ciudad de Buenos Aires, C1094AAD, Argentina

  • Research Site

    Mendoza, 5500, Argentina

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    Ramos Mejía, B1704ETD, Argentina

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    Rosario, S2000PBJ, Argentina

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    San Nicolás, B2900DMH, Argentina

  • Research Site

    Botany, 2019, Australia

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    Helensvale, 4212, Australia

  • Research Site

    Kotara, 2289, Australia

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    Malvern, 3144, Australia

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    Maroubra, 2035, Australia

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    Waitara, 2077, Australia

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    Calgary, Alberta, T3R 1W9, Canada

  • Research Site

    Vancouver, British Columbia, V5Y 3W2, Canada

  • Research Site

    Moncton, New Brunswick, E1G 1A7, Canada

  • Research Site

    Truro, Nova Scotia, B2N 1L2, Canada

  • Research Site

    Hamilton, Ontario, L8L 5G8, Canada

  • Research Site

    Markham, Ontario, L3S 0A2, Canada

  • Research Site

    North York, Ontario, M6B 3H7, Canada

  • Research Site

    Sarnia, Ontario, N7T 4X3, Canada

  • Research Site

    Scarborough Village, Ontario, M1R 0B1, Canada

  • Research Site

    Stoney Creek, Ontario, L8J 3W2, Canada

  • Research Site

    Stouffville, Ontario, L4A1H2, Canada

  • Research Site

    Toronto, Ontario, M4G3E8, Canada

  • Research Site

    Toronto, Ontario, M6G 1M2, Canada

  • Research Site

    Joliette, Quebec, J6E 6A9, Canada

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    Montreal, Quebec, H4J 1E3, Canada

  • Research Site

    Montreal, Quebec, H4N 2W2, Canada

  • Research Site

    Québec, Quebec, G2J 0C4, Canada

  • Research Site

    Trois-Rivières, Quebec, G9A 4P3, Canada

  • Research Site

    Concepción, 4070060, Chile

  • Research Site

    Concepción, 4070196, Chile

  • Research Site

    Concepción, 4070566, Chile

  • Research Site

    Iquique, 1111442, Chile

  • Research Site

    Providencia, 7500504, Chile

  • Research Site

    Santiago, 7510187, Chile

  • Research Site

    Santiago, 7691236, Chile

  • Research Site

    Santiago, 8331143, Chile

  • Research Site

    Santiago, Chile

  • Research Site

    Beijing, 100050, China

  • Research Site

    Cangzhou, 061001, China

  • Research Site

    Changchun, 130011, China

  • Research Site

    Chengdu, 610021, China

  • Research Site

    Chengdu, 610072, China

  • Research Site

    Danyang, 212399, China

  • Research Site

    Ganzhou, 341000, China

  • Research Site

    Guangzhou, 510280, China

  • Research Site

    Huizhou, 516002, China

  • Research Site

    Huzhou, 313003, China

  • Research Site

    Lanzhou, 730000, China

  • Research Site

    Nanjing, 210008, China

  • Research Site

    Nanjing, 210009, China

  • Research Site

    Panjin, 124009, China

  • Research Site

    Suzhou, 215006, China

  • Research Site

    Xianyang, 712000, China

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    Berlin, 10117, Germany

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    Berlin, 10629, Germany

  • Research Site

    Bochum, 44789, Germany

  • Research Site

    Bünde, 32257, Germany

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    Dresden, 01069, Germany

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    Frankfurt, 60590, Germany

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    Frankfurt, 60596, Germany

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    Freiburg im Breisgau, 79106, Germany

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    Göttingen, 37075, Germany

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    Hamburg, 20095, Germany

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    Hamburg, 20253, Germany

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    Hanover, 30159, Germany

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    Homburg, 66421, Germany

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    Jerichow, 39319, Germany

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    Karlsruhe, 76137, Germany

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    Leipzig, 04177, Germany

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    Magdeburg, 39110, Germany

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    Mainz, 55128, Germany

  • Research Site

    München, 80339, Germany

  • Research Site

    Offenbach, 63065, Germany

  • Research Site

    Balatonfüred, 8230, Hungary

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    Budapest, 1024, Hungary

  • Research Site

    Budapest, 1036, Hungary

  • Research Site

    Budapest, 1132, Hungary

  • Research Site

    Budapest, 1138, Hungary

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    Debrecen, 4031, Hungary

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    Debrecen, 4032, Hungary

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    Miskolc, 3530, Hungary

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    Nyíregyháza-Sóstóhegy, 4481, Hungary

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    Szeged, 6725, Hungary

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    Szolnok, 5000, Hungary

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    Bangalore, 560092, India

  • Research Site

    Indore, 452010, India

  • Research Site

    Kolkata, 700014, India

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    Nagpur, 440010, India

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    Pune, 411021, India

  • Research Site

    Pune, 411057, India

  • Research Site

    Siliguri, 734012, India

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    Visakhapatnam, 530002, India

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    Aira, 899-5421, Japan

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    Hachioji-shi, 192-0071, Japan

  • Research Site

    Izunokuni-shi, 410-2295, Japan

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    Kumamoto, 860-0833, Japan

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    Nagoya, 451-8511, Japan

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    Nagoya, 467-0806, Japan

  • Research Site

    Nerima-ku, 177-0051, Japan

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    Osaka, 537-0014, Japan

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    Osaka, 540-0006, Japan

  • Research Site

    Saga, 840-8571, Japan

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    Tanabe-shi, 646-8558, Japan

  • Research Site

    Bialystok, 15-481, Poland

  • Research Site

    Elblag, 82-300, Poland

  • Research Site

    Gdynia, 81-338, Poland

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    Katowice, 40-081, Poland

  • Research Site

    Katowice, 40-772, Poland

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    Krakow, 30-105, Poland

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    Krakow, 31-271, Poland

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    Legnica, 59-220, Poland

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    Lodz, 90-132, Poland

  • Research Site

    Lodz, 90-338, Poland

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    Poznan, 60-354, Poland

  • Research Site

    Radzionków, 41-922, Poland

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    Warsaw, 00-719, Poland

  • Research Site

    Warsaw, 03-291, Poland

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    Wroclaw, 53-673, Poland

  • Research Site

    Bratislava, 831 03, Slovakia

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    Bratislava, 83101, Slovakia

  • Research Site

    Bratislava, 83106, Slovakia

  • Research Site

    Košice, 040 01, Slovakia

  • Research Site

    Košice, 04022, Slovakia

  • Research Site

    Lučenec, 984 01, Slovakia

  • Research Site

    Námestovo, 02901, Slovakia

  • Research Site

    Prievidza, 97101, Slovakia

  • Research Site

    Rožňava, 048 01, Slovakia

  • Research Site

    Trebišov, 075 01, Slovakia

  • Research Site

    Busan, 48108, South Korea

  • Research Site

    Daegu, 42601, South Korea

  • Research Site

    Daejeon, 35233, South Korea

  • Research Site

    Incheon, 403-720, South Korea

  • Research Site

    Seoul, 01830, South Korea

  • Research Site

    Seoul, 06351, South Korea

  • Research Site

    Seoul, 08308, South Korea

  • Research Site

    Seoul, 143729, South Korea

  • Research Site

    Seoul, 150-713, South Korea

  • Research Site

    Suwon, 16247, South Korea

  • Research Site

    A Coruña, 15006, Spain

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    Alzira, 46600, Spain

  • Research Site

    Barcelona, 08035, Spain

  • Research Site

    Ferrol, 15405, Spain

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    Lleida, 25198, Spain

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    Málaga, 29010, Spain

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    Oviedo, 33011, Spain

  • Research Site

    Segovia, 40002, Spain

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    Seville, 41010, Spain

  • Research Site

    Seville, 41950, Spain

  • Research Site

    Changhua, 500, Taiwan

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    Kaohsiung City, 80756, Taiwan

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    Taichung, 402, Taiwan

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    Taichung, 404, Taiwan

  • Research Site

    Taichung, 407219, Taiwan

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    Taichung, 433004, Taiwan

  • Research Site

    Tainan, 704, Taiwan

  • Research Site

    Tainan, 710, Taiwan

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    Taipei, 10002, Taiwan

  • Research Site

    Taipei, 11490, Taiwan

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    Zhubei, 302, Taiwan

  • Research Site

    Chippenham, SN15 2SB, United Kingdom

  • Research Site

    Corby, NN17 2UR, United Kingdom

  • Research Site

    Corby, NN18 9EZ, United Kingdom

  • Research Site

    Dunfermline, KY12 0SU, United Kingdom

  • Research Site

    Hull, HU3 2PA, United Kingdom

  • Research Site

    Northwood, HA6 2RN, United Kingdom

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