Ayahuasca or esketamine: which eases depression better?

NCT ID NCT07212946

First seen Nov 01, 2025 · Last updated Jun 11, 2026 · Updated 28 times

Summary

This study tested whether four weekly doses of ayahuasca (a plant-based psychedelic drink) or esketamine (a nasal spray) could reduce symptoms in 22 adults with severe major depression. Participants were randomly assigned to one treatment, and their depression levels were tracked using a standard questionnaire. The goal was to see which approach works better for easing depression.

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Contacts and locations

Locations

  • Hospital das Clínicas da FMRP-USP

    Ribeirão Preto, São Paulo, 14049900, Brazil

Conditions

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