Ayahuasca or esketamine: which eases depression better?

This study tested whether four weekly doses of ayahuasca (a plant-based psychedelic drink) or esketamine (a nasal spray) could reduce symptoms in 22 adults with severe major depression. Participants were randomly assigned to one treatment, and their depression levels were tracked using a standard questionnaire. The goal was to see which approach works better for easing depression.