Tailored surgery may save lives in aortic dissection

NCT ID NCT05912608

ENROLLING_BY_INVITATION Disease control Sponsor: Centre Cardiologique du Nord Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at two surgical approaches for repairing a tear in the aorta (the main artery from the heart) in 900 patients. One approach is less invasive (root-sparing), used for higher-risk patients, while the other is more extensive (root replacement and total arch repair), used for lower-risk patients. The goal is to see which strategy leads to fewer deaths and complications like stroke or heart attack.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: surgical procedure (root-sparing or root replacement with arch repair)
What this could lead to: If successful, this study could help surgeons choose the safest and most effective surgery for each patient with aortic dissection, potentially reducing deaths and complications.
What could go wrong: This is an observational study, not a randomized trial, so results may be influenced by patient selection. The surgeries themselves carry serious risks like stroke, heart attack, and spinal cord injury.

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Conditions

The condition(s) this trial relates to.

Aortic Dissection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC DISSECTION

Contacts and locations

Locations

Francesco Nappi

Saint-Denis, 93200, France

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