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AI vs. human: which physical therapy wins for knee pain?

NCT ID NCT07774195

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This trial tests whether an AI-generated physical therapy program can be as effective as traditional rehab for people with knee osteoarthritis. Forty adults aged 45-70 with moderate knee osteoarthritis will be randomly assigned to either an AI-guided program created by ChatGPT-4 or a conventional program with TENS, strengthening, and balance exercises. Researchers will compare pain, knee movement, function, and fall risk before and after treatment to see if the AI approach holds up.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
AI-guided physical therapy program generated using ChatGPT-4
What this could lead to
If effective, AI-guided physical therapy could offer a personalized, accessible alternative to traditional rehab for knee osteoarthritis.
What could go wrong
The trial is small (40 participants) and early-stage, so results may not apply broadly. AI-generated programs may lack the nuance of human therapists.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants will be recruited through outpatient orthopedic clinics and community health centers affiliated with the study sites. * Their age will be ranged from 45-70 years. * Their body mass index (BMI) will be ranged from 24.9 to 30 kg /m2 . * With a clinical and radiographic diagnosis of knee osteoarthritis based on American College of Rheumatology criteria, with Kellgren-Lawrence grade II or III osteoarthritis, and who will able to ambulate * Independently walk without assistive devices. Exclusion Criteria: * Prior knee replacement surgery, inflammatory arthritis (e.g., rheumatoid arthritis). * Recent intra-articular steroid injections within three months. * Neurologic impairments affecting lower limb function. * Inability to comprehend or use the mobile application due to cognitive or sensory impairments.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Knee osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of physical therapy, Cairo University

    Giza, Egypt

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