Can an ADHD drug also cut cannabis use?

NCT ID NCT07838311

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 24, 2026 · Last updated Sep 25, 2026 · Updated 1 time

Summary

Researchers are testing whether a long-acting form of methylphenidate, an FDA-approved ADHD medication sold as Jornay PM, can reduce ADHD symptoms in people aged 16 to 26 who also have cannabis use disorder. Half of the participants take the medication every night for 12 weeks, and the other half take a placebo. The team measures changes in ADHD severity and in how many days participants use cannabis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
delayed-release, extended-release methylphenidate, also known as Jornay PM
What this could lead to
If it works, this could give doctors a medication option for people who have both ADHD and cannabis use disorder, a combination that is hard to treat.
What could go wrong
The study is small, with 66 participants, and it tests an ADHD drug for a use it is not approved for. Methylphenidate can cause side effects like trouble sleeping, appetite loss, and a fast heartbeat, and the results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Nov 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 26 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female subjects, 16-26 years of age at the time of consent 2. An established diagnosis of ADHD and CUD based on the DSM-5 3. ADHD severity of 4 or greater as determined by the Clinical Global Impression-Severity (CGI-S) scale 4. Subject must be interested in or currently participating in some type of treatment for their CUD, including, but not limited to, outpatient individual therapy, outpatient group therapy, CUD-directed pharmacotherapy, Marijuana Anonymous, Alcoholics Anonymous, or Narcotics Anonymous 5. Subject must report cannabis use on at least 3 of the 7 days prior to study enrollment 6. Subject must have a level of understanding sufficient to communicate intelligently with the investigator and study staff to complete study tasks in English 7. Subject must be willing to cooperate with all tests and examinations required by the protocol 8. Subject must be domiciled in the state of Massachusetts Exclusion Criteria: 1. Subjects who are pregnant or nursing, or subjects unable or unwilling to use birth control. Birth control includes, but is not limited to: * i. hormonal methods, such as birth control pills, patches, injections, vaginal rings, or implants * ii. barrier methods (such as a condom or diaphragm) used with a spermicide (a foam, cream, or gel that kills sperm) * iii. intrauterine device (IUD) * iv. abstinence (no sex) 2. Subjects who present a negative urine dipstick result for cannabis use at baseline or report fewer than 3 use days of cannabis in week preceding study enrollment 3. Subjects with major untreated psychopathology, psychosis, suicidality, or concurrent active non-nicotine SUD other than CUD that, in the investigators' opinion, place them at risk for the adverse effects or need for additional care 4. Subjects who are unwilling or unable to comply with study procedures 5. Subjects who refuse additional substance-related interventions 6. Subjects with known medical risk factors (e.g., known untreated hypertension, arrhythmia, premature family history of sudden death) and active symptoms that, in the investigators' opinion, place them at risk for untoward adverse effects 7. Subjects with previous poor response or poor tolerability to methylphenidate 8. Investigator and his/her immediate family; defined as the investigator's spouse, parent, child, grandparent, or grandchild 9. Subjects who are unable to swallow large capsules 10. Subjects with a known allergy to study medication or known hypersensitivity to methylphenidate HCL or product components 11. Subjects with concurrent treatment with a monoamine oxidase inhibitor (MAOI) or use of an MAOI within the preceding 14 days 12. Subjects who have ever taken Jornay PM in the past

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Massachusetts General Hospital, 55 Fruit Street, Yawkey 6A

    Boston, Massachusetts, 02114, United States

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