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Can a Baby's brain scans predict ADHD years later?

NCT ID NCT07836244

Knowledge-focused Sponsor: First Affiliated Hospital Xi'an Jiaotong University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
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First seen Sep 23, 2026 · Last updated Sep 24, 2026 · Updated 1 time

Summary

Researchers are following babies with neonatal white matter injury to see whether early brain changes are linked to ADHD later in childhood. The study combines retrospective and prospective cohorts, using MRI scans and standardized developmental and behavioral assessments from infancy through childhood. They aim to identify which imaging features, such as white matter microstructure and structural disconnection, are associated with ADHD-related outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If researchers find MRI markers that predict ADHD after neonatal white matter injury, doctors could flag at-risk children earlier and start support sooner.
What could go wrong
This is an observational study, so it can show links but not prove that white matter injury causes ADHD. Many children with early brain injury develop typically, and ADHD has many other genetic and environmental contributors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

348 people

The number who actually took part.

Started

Jan 2023

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population is derived from a multicenter neonatal and infant clinical and multimodal MRI database established through a national research project. The database includes clinical information and multimodal MRI data collected from multiple clinical centers. This bidirectional observational cohort study includes neonates with white matter injury (WMI) identified on brain MRI and control neonates without apparent abnormalities on routine MRI. Eligible participants will be screened from the existing database, and clinical characteristics, MRI findings, and longitudinal neurobehavioral outcomes will be analyzed to investigate the association between neonatal brain injury patterns and later developmental outcomes.

Ages

1 day and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Neonates diagnosed with white matter injury (WMI) or neonates without obvious abnormalities on routine MRI examination from the multicenter database. * Brain MRI examination performed within 28 days after birth, with gestational age ≤42 weeks at examination. * Complete MRI data available, including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), and diffusion tensor imaging (DTI). * Complete maternal and pregnancy history information, neonatal demographic characteristics, and clinical information available. Exclusion Criteria: * Congenital nervous system developmental malformations or suspected genetic or metabolic diseases. * Obvious MRI artifacts affecting image evaluation. * Inability to complete follow-up neurobehavioral assessments.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder Leukoaraiosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHD Neurodevelopment outcome White matter abnormalities, nonspecific

Contacts and locations

Locations

  • Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University

    Hangzhou, China

  • Children's Hospital of Soochow University

    Suzhou, China

  • First Affiliated Hospital of Xi'an Jiaotong University

    Xi'an, Shaanxi, China

  • Gansu Province Maternity and Child Health Hospital

    Lanzhou, China

  • Hebei Children's Hospital

    Shijiazhuang, China

  • Northwest Women's and Children's Hospital

    Xi'an, China

  • Qinghai Red Cross Hospital

    Qinghai, China

  • The Second Affiliated Hospital of Shaanxi University of Chinese Medicine

    Xianyang, China

  • Wuxi Children's Hospital

    Wuxi, China

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