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New drug may boost protein levels in heart disease patients

NCT ID NCT07298044

Recruiting now Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether switching from tafamidis to acoramidis can raise blood levels of transthyretin (TTR) in adults with transthyretin amyloid cardiomyopathy (ATTR-CM). The drug acoramidis stabilizes TTR to prevent harmful amyloid clumps that stiffen the heart. Researchers will measure TTR levels over 6 months in 50 participants who have already been on tafamidis. The goal is to see if acoramidis works better at keeping TTR stable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

acoramidis (a drug that stabilizes the TTR protein to prevent amyloid buildup)

What this could lead to

If successful, this study could show that acoramidis raises TTR levels more than tafamidis, potentially offering a better option for managing ATTR-CM.

What could go wrong

This is a small, early-phase study with only 50 participants and no placebo group. It measures a lab marker (TTR level), not long-term heart outcomes, so benefits are uncertain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRANSTHYRETIN AMYLOID CARDIOMYOPATHY

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • AZ St-Jan Brugge-Oostende A.V.

    NOT_YET_RECRUITING

    Bruges, West Flanders, 8000, Belgium

  • Azienda Ospedale-Università di Padova-UOC Cardiologia

    NOT_YET_RECRUITING

    Padova, 35128, Italy

  • Azienda Ospedaliera Dei Colli_Monaldi - Malattie Rare e Genetiche Cardiovascolari

    NOT_YET_RECRUITING

    Naples, 80131, Italy

  • Azienda Ospedaliera Universitaria Senese - cardiologia

    RECRUITING

    Siena, 53100, Italy

  • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola_Cardiologia

    NOT_YET_RECRUITING

    Bologna, 40138, Italy

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1

    RECRUITING

    Bergamo, 24127, Italy

  • Careggi University Hospital_cardio intensive care unit

    NOT_YET_RECRUITING

    Florence, 50134, Italy

  • Centro Cardiologico Monzino S.p.A. - Cardiologia Peri-Operatoria e Imaging Cardiovascolare

    RECRUITING

    Milan, 20138, Italy

  • Fondazione IRCCS Policlinico San Matteo-SC Medicina Generale 2 - Centro Amiloidosi Sistemiche e Malattie ad Alta Complessità

    NOT_YET_RECRUITING

    Pavia, 27100, Italy

  • Fondazione Toscana Gabriele Monasterio_Pisa - Cardiologia e Medicina Cardiovascolare

    RECRUITING

    Pisa, 56124, Italy

  • Hôpital Erasme/Erasmus Ziekenhuis

    NOT_YET_RECRUITING

    Brussels, Brussels Capital, 1070, Belgium

  • KVZ Kardiovaskulaeres Zentrum Darmstadt GmbH

    NOT_YET_RECRUITING

    Darmstadt, Hesse, 64287, Germany

  • Klinik Favoriten - 5.Medizinische Abteilung-Kardiologie

    NOT_YET_RECRUITING

    Vienna, State of Vienna, 1100, Austria

  • Klinik Ottakring - 3. Medizinische Abteilung mit Kardiologie, internistischer Intensivmedizin und Ambulanz

    NOT_YET_RECRUITING

    Vienna, State of Vienna, 3500, Austria

  • Krankenhaus St. Josef Braunau | Innere Medizin I

    NOT_YET_RECRUITING

    Braunau am Inn, Upper Austria, 5280, Austria

  • Medizinische Universität Graz- Klinische Abteilung für Kardiologie

    RECRUITING

    Vienna, Styria, 1030, Austria

  • Medizinische Universität Wien- Universitätsklinik für Innere Medizin II, Klinische Abteilung für Kardiologie

    RECRUITING

    Vienna, State of Vienna, 1090, Austria

  • Ospedale Vito Fazzi Lecce_Cardiologia e UTIC

    NOT_YET_RECRUITING

    Lecce, 73100, Italy

  • Universitätsklinikum St. Pölten - Lilienfeld - Klinische Abteilung für Innere Medizin 3

    WITHDRAWN

    Sankt Pölten, Lower Austria, 1210, Austria

  • VIVIT - Landeskrankenhaus Feldkirch - Innere Medizin I, Kardiologie, Angiologie, Endokrinologie, Diabetologie, Intensivmedizin

    WITHDRAWN

    Feldkirch, Vorarlberg, 6800, Austria