New drug may boost protein levels in heart disease patients
NCT ID NCT07298044
First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times
Summary
This study tests whether switching from tafamidis to acoramidis can raise blood levels of transthyretin (TTR) in adults with transthyretin amyloid cardiomyopathy (ATTR-CM). The drug acoramidis stabilizes TTR to prevent harmful amyloid clumps that stiffen the heart. Researchers will measure TTR levels over 6 months in 50 participants who have already been on tafamidis. The goal is to see if acoramidis works better at keeping TTR stable.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- acoramidis (a drug that stabilizes the TTR protein to prevent amyloid buildup)
- What this could lead to
- If successful, this study could show that acoramidis raises TTR levels more than tafamidis, potentially offering a better option for managing ATTR-CM.
- What could go wrong
- This is a small, early-phase study with only 50 participants and no placebo group. It measures a lab marker (TTR level), not long-term heart outcomes, so benefits are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AZ St-Jan Brugge-Oostende A.V.
NOT_YET_RECRUITINGBruges, West Flanders, 8000, Belgium
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Azienda Ospedale-Università di Padova-UOC Cardiologia
NOT_YET_RECRUITINGPadova, 35128, Italy
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Azienda Ospedaliera Dei Colli_Monaldi - Malattie Rare e Genetiche Cardiovascolari
NOT_YET_RECRUITINGNaples, 80131, Italy
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Azienda Ospedaliera Universitaria Senese - cardiologia
RECRUITINGSiena, 53100, Italy
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Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola_Cardiologia
NOT_YET_RECRUITINGBologna, 40138, Italy
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Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII - Cardiologia 1
RECRUITINGBergamo, 24127, Italy
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Careggi University Hospital_cardio intensive care unit
NOT_YET_RECRUITINGFlorence, 50134, Italy
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Centro Cardiologico Monzino S.p.A. - Cardiologia Peri-Operatoria e Imaging Cardiovascolare
RECRUITINGMilan, 20138, Italy
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Fondazione IRCCS Policlinico San Matteo-SC Medicina Generale 2 - Centro Amiloidosi Sistemiche e Malattie ad Alta Complessità
NOT_YET_RECRUITINGPavia, 27100, Italy
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Fondazione Toscana Gabriele Monasterio_Pisa - Cardiologia e Medicina Cardiovascolare
RECRUITINGPisa, 56124, Italy
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Hôpital Erasme/Erasmus Ziekenhuis
NOT_YET_RECRUITINGBrussels, Brussels Capital, 1070, Belgium
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KVZ Kardiovaskulaeres Zentrum Darmstadt GmbH
NOT_YET_RECRUITINGDarmstadt, Hesse, 64287, Germany
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Klinik Favoriten - 5.Medizinische Abteilung-Kardiologie
NOT_YET_RECRUITINGVienna, State of Vienna, 1100, Austria
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Klinik Ottakring - 3. Medizinische Abteilung mit Kardiologie, internistischer Intensivmedizin und Ambulanz
NOT_YET_RECRUITINGVienna, State of Vienna, 3500, Austria
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Krankenhaus St. Josef Braunau | Innere Medizin I
NOT_YET_RECRUITINGBraunau am Inn, Upper Austria, 5280, Austria
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Medizinische Universität Graz- Klinische Abteilung für Kardiologie
RECRUITINGVienna, Styria, 1030, Austria
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Medizinische Universität Wien- Universitätsklinik für Innere Medizin II, Klinische Abteilung für Kardiologie
RECRUITINGVienna, State of Vienna, 1090, Austria
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Ospedale Vito Fazzi Lecce_Cardiologia e UTIC
NOT_YET_RECRUITINGLecce, 73100, Italy
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Universitätsklinikum St. Pölten - Lilienfeld - Klinische Abteilung für Innere Medizin 3
WITHDRAWNSankt Pölten, Lower Austria, 1210, Austria
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VIVIT - Landeskrankenhaus Feldkirch - Innere Medizin I, Kardiologie, Angiologie, Endokrinologie, Diabetologie, Intensivmedizin
WITHDRAWNFeldkirch, Vorarlberg, 6800, Austria
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