Western University, Canada

This study tests whether mepolizumab, an injectable medication, can improve lung ventilation and reduce mucus plugs in adults with COPD who have elevated eosinophils. Participants receive mepolizumab every 4 weeks for 48 weeks and undergo MRI and CT scans along with breathing tes…

This study compares two surgical techniques—labral repair and labral reconstruction—for treating hip impingement in people over 40. Researchers will enroll 220 participants to see which approach better improves hip function and pain. The goal is to determine if a larger trial is …

This study will test whether a 12-week group exercise program is safe and practical for people with osteoporosis who have recently had a fracture. One hundred participants will attend twice-weekly classes and undergo bone scans and interviews. The goal is to see if this type of p…

This study looks at whether supervised exercise and the diabetes drug semaglutide, alone or together, can improve thinking and brain health in older adults with type 2 diabetes. About 164 people aged 65 and older will take part. They will be assigned to exercise training, a contr…

This study tests a mobile app designed for people with functional movement disorder (FMD), a condition where the brain doesn't send movement signals properly. The app lets users record symptoms, stress, and mood as they happen, and offers simple self-help tools. Ten adults with F…

This study tests whether small changes—like playing calming music, showing a relaxing video, or giving numbing gel at the right time—can reduce pain and anxiety during a bladder cancer exam or treatment. About 378 adults with bladder cancer will be randomly assigned to receive on…

This study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'cli…

This study compares how the body absorbs ketamine when taken as a pill versus under the tongue in people with major depression. Ten adults will try both forms in a crossover design, with blood samples measuring drug levels. The goal is to find safe, effective doses for these chea…

This study looks at how people with functional movement disorders (FMD) experience a sense of control over their actions. Researchers will measure how quickly participants respond when asked if they caused an action, using a computer task. The goal is to develop a more objective …