West Virginia University

This early-stage trial tests whether adding leflunomide to the standard drug decitabine is safe and effective for people with myelodysplastic syndromes (MDS) that have returned or not responded to prior treatment. About 26 adults will receive the combination in cycles. The main g…

This study tests whether adding hydroxychloroquine (a malaria drug) to standard chemotherapy before surgery can improve outcomes for people with resectable pancreatic cancer. About 40 participants will receive the drug combo, then undergo surgery to remove their tumor. The goal i…

This study tests whether giving heated chemotherapy directly into the abdomen during surgery is safe for people with high-risk gallbladder cancer. The treatment aims to prevent cancer from coming back in the belly lining. Ten participants will be enrolled to check for complicatio…

This study is for people with blood cancers like leukemia who are getting chemotherapy or a stem cell transplant, which can cause very low white blood cell counts (neutropenia) for over a week. The goal is to see if the antibiotic eravacycline can prevent serious bacterial infect…

This study tests a drug called blinatumomab, given as a shot under the skin, for adults with a rare type of leukemia called mixed phenotype acute leukemia (MPAL). The trial includes three groups: newly diagnosed patients who cannot have strong chemo, patients in remission but wit…

This study is testing whether injecting cooled or warmed salt water (saline) directly into lipomas—harmless fatty lumps under the skin—can shrink them. About 20 adults with at least one lipoma will receive up to four treatments, each four weeks apart. The goal is to see if this s…

This early study tests whether adding aluminum chloride hexahydrate, a drug that stops bleeding, to standard 5-fluorouracil cream works better for actinic keratoses—rough, scaly spots from sun damage that can turn into skin cancer. About 32 adults will apply one of two creams to …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who are on dopamine therapy. Twenty participants will receive both real and sham stimulation in random order, then complete task…

This study tests a nurse-led home care program for people with advanced heart failure and their family caregivers in rural Appalachia. The program uses faith-based nurses and local volunteers to improve quality of life and reduce symptoms. About 208 patients and their caregivers …

This study tests whether a simple, 45-minute resistance exercise program (using bands) can help breast cancer survivors manage fatigue. Researchers will enroll 60 women from different income backgrounds to see if the program is practical and if income affects how well people stic…

This study is a registry that will follow 50 adults who are already scheduled to receive EUS-guided radiofrequency or microwave ablation for pancreatic or other gastrointestinal lesions as part of their routine care. Researchers will collect data from medical records to see how t…

This study adapts a suicide risk screening program called the NIMH Clinical Pathway for use in two school-based health centers in rural West Virginia. Researchers will work with 30 participants—students, parents, and providers—to see if the program is practical and effective at i…

This study looks at whether filtering out blue light at night in hospital rooms can reduce inflammation, protect thinking skills, and improve mood and sleep in 80 adults having elective heart surgery. Participants will be randomly assigned to wear blue-blocking glasses or regular…

This study looks at how different doses of CBD oil affect driving performance in 300 healthy adults aged 18-30. Participants will take CBD or a placebo and then use a driving simulator to measure weaving, crashes, and reaction time. The goal is to understand if CBD causes drowsin…