University Of Vermont

This study tested whether giving pregnant smokers cigarettes with very low nicotine (0.4 mg per gram of tobacco) helps them smoke less over 12 weeks. Thirty women were randomly assigned to either their usual brand or the low-nicotine cigarettes. The main goal was to see if they s…

This study tested whether offering financial incentives through a smartphone app could help pregnant women stop smoking. 150 women who smoked were randomly assigned to either earn rewards for submitting breath and saliva tests showing no smoking, or to receive standard care. The …

This early-phase trial tested whether injecting the chemotherapy drug cisplatin directly into lung tumors (during a bronchoscopy) is safe for people with early-stage, resectable non-small cell lung cancer. Only 6 participants were enrolled, and the main goal was to find the highe…

This study tested whether delivering pre-made meals to the homes of people in treatment for opioid use disorder could help with food insecurity. Fifty adults were split into two groups: one got nutrition education and community resources, while the other also received weekly meal…

This pilot study tested whether offering small financial rewards for clean urine samples could help people who use stimulants stay abstinent. 27 participants from a syringe exchange program were randomly assigned to either earn money for negative drug tests or receive health educ…

This study looked at whether adding a type of talk therapy called prolonged exposure therapy (PET) to standard opioid addiction treatment can help reduce PTSD symptoms. 82 adults with both opioid use disorder and PTSD took part. Some got only addiction treatment, while others als…

This pilot study tested whether a remote digital exercise program (Vitala app) is feasible and helpful for adults with obesity and poorly controlled asthma. Twenty participants received a tailored exercise prescription and were encouraged to complete 150 minutes of activity per w…

This completed Phase 1 trial tested whether MitoQ, a drug that targets cell energy centers, can improve airway reactivity in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo daily for 12 weeks. The study aimed to see if MitoQ could help control …

This study looked at how menopause-related hormone changes affect brain function and Alzheimer's risk in 120 postmenopausal women aged 50-70. Researchers used memory tests and brain scans to see which women's brains coped well with hormone changes and which showed signs of future…

This early-phase study looked at how the body handles zinc in people with severe sepsis, a life-threatening infection that causes organ failure. Researchers gave different doses of intravenous zinc to 40 ICU patients on breathing machines and compared them to 15 healthy volunteer…

This study tested whether using a device that sends mild electrical pulses to the leg muscles (NMES) could help older adults recover strength and mobility after being hospitalized for a COPD flare-up or pneumonia. Seven participants used the device in the hospital and at home for…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This study tested whether a single 1650 mg dose of choline, a nutrient found in foods like eggs and meat, affects brain activity in postmenopausal women. Thirty-eight healthy women aged 50–65 took either choline or a placebo and had their brains scanned with fMRI while doing a me…

This study looked at why leg muscles shrink and get weaker right after total knee replacement surgery. Researchers studied 23 adults with knee osteoarthritis before and after their operation. They measured muscle fibers, energy-producing parts of cells, and physical activity to f…