Chemo shot straight to lung tumors tested in tiny trial

NCT ID NCT04809103

Completed Disease control Sponsor: University of Vermont Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tested whether injecting the chemotherapy drug cisplatin directly into lung tumors (during a bronchoscopy) is safe for people with early-stage, resectable non-small cell lung cancer. Only 6 participants were enrolled, and the main goal was to find the highest safe dose. The study is complete, but it is too small and early to know if this approach works better than standard treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cisplatin
What this could lead to: If it works, this could point toward a new way to deliver chemotherapy directly into lung tumors, potentially reducing side effects.
What could go wrong: This is a very early, small phase 1 trial with only 6 participants, focused on safety and dosing. It is not designed to prove effectiveness, and the approach may not work or may cause unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

University of Vermont

Burlington, Vermont, 05405, United States

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