Stony Brook University

This study tests a new approach for people newly diagnosed with glioblastoma, an aggressive brain cancer. Participants receive a short course of targeted radiation plus an immunotherapy drug (atezolizumab) before surgery to remove the tumor. The goal is to see if this combination…

This study tests whether a nerve block can help reduce the need for strong painkillers (opioids) after neck surgery. About 60 people having posterior cervical spine surgery will be randomly assigned to receive either the nerve block plus standard pain medication or standard pain …

This study aims to find better ways to treat depression in people with chronic kidney disease (CKD). About 201 adults with advanced CKD and major depression will receive either behavioral activation teletherapy plus a non-SSRI antidepressant, the antidepressant plus teletherapy, …

This study tests a brief motivational program to help 84 cancer survivors who are part of the World Trade Center Health Program become more physically active. Participants will wear a Fitbit to track their activity, and the goal is to increase moderate-to-vigorous exercise by 25%…

This study compares using a Foley balloon plus misoprostol versus standard osmotic dilators (Laminaria) to prepare the cervix before a second-trimester surgical abortion (16-21 weeks). About 102 women in Mozambique will take part. The goal is to see if the balloon method works ju…

This early study tests whether a non-invasive device that gently stimulates a nerve in the ear is safe and practical for ICU patients with delirium (sudden confusion). Ten right-handed adults with delirium will receive 30-minute ear stimulation sessions twice daily for up to 7 da…

This study looks at whether coloring can help adults feel less pain and anxiety while they wait in the emergency room. About 168 people with moderate pain or anxiety will be given nature or geometric coloring sheets to use. Researchers will measure changes in their self-reported …

This study looks at how different energy sources (glucose and ketones) affect brain activity and behavior in people with bipolar disorder. Participants will have MRI scans while playing money-winning games before and after drinking glucose or ketones. Researchers will compare res…

This study looks at how a brain protein called mGluR5 might be involved in why treating insomnia with therapy (CBT-I) also helps depression. About 42 adults with major depression and trouble sleeping will get CBT-I and have brain scans and sleep tests. The goal is to understand t…

This study is testing a decision aid for people with small thyroid nodules that are either cancerous or have a chance of being cancerous. The goal is to see if the tool helps patients choose a treatment that matches their personal values. About 134 participants will fill out surv…

This study looks at how fear and anxiety about anesthesia change in people who have never had it before. About 40 adults scheduled for low-risk surgeries will fill out surveys before their procedure and answer follow-up questions a few days later. The goal is to understand their …

This study tests a computer system called SeeMe that uses cameras to detect very small movements in people with severe traumatic brain injury. Current exams can miss these movements, leading to misdiagnosis. The goal is to see if SeeMe can find signs of consciousness earlier and …