Stephan Grupp Md Phd

This study tests whether a stem cell transplant using the patient's own cells can help young people (ages 8 to 25) with life-threatening lupus or scleroderma. The goal is to wipe out the faulty immune system and allow a new, healthy one to grow. The trial will track how long pati…

This early-phase study tests a personalized cell therapy called CART123, made from a patient's own immune cells, to treat children and young adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatments. Some participants will receive CART123 …

This early-phase study tests BEAM-201, a type of immune cell therapy made from donor cells, in children and young adults up to age 29 with T-cell acute lymphoblastic leukemia or lymphoma that has returned or not responded to standard treatments. The goal is to find a safe dose an…

This early-phase trial tests a new type of immune cell therapy (PHOX2B PC-CAR T cells) in children with relapsed or high-risk neuroblastoma that has not responded to standard treatments. The main goal is to find a safe dose and see how the body reacts. About 38 children aged 1 an…

This study tests a treatment called CART19, which uses a patient's own immune cells modified to attack cancer cells. It is for children and young adults with certain high-risk types of B-cell acute lymphoblastic leukemia (B-ALL), including those with a central nervous system rela…

This early-stage trial tests a new treatment called GPC2 CAR T cells for children with advanced neuroblastoma or retinoblastoma that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to better recognize and atta…

This study tests a new approach for children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to treatment. Participants receive two different types of their own modified immune cells (CAR T cells) designed to target two protei…

This study is for children with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to standard treatments. Researchers are testing a new way to make special immune cells (CAR T-cells) that can find and kill cancer cells. The goal is to see if this new…