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New hope for kids with tough leukemia: smarter CAR T-Cell production under study

NCT ID NCT05480449

Recruiting now Disease control Sponsor: Stephan Grupp MD PhD Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 28 times

Summary

This study is for children with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to treatment. Researchers are testing a new way to make special immune cells, called CAR T-cells, using a machine called CliniMACS Prodigy. The goal is to see if this new manufacturing method is safe and works better at fighting the cancer. About 89 children will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Children's Hospital of Philadelphia

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

B LINEAGE LYMPHOBLASTIC LYMPHOMA B LINEAGE LYMPHOBLASTIC LYMPHOMA B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL)