Otsuka Pharmaceutical Development & Commercialization, Inc.

This study tests whether a new drug called quabodepistat, combined with other TB medicines, can treat drug-resistant tuberculosis (TB) in just 4 months instead of the usual 6 months. About 532 adults and teens with rifampicin-resistant or multidrug-resistant TB will take part. Th…

This study tests an oral drug called JNT-517 for adults with phenylketonuria (PKU), a genetic condition that causes harmful buildup of phenylalanine (Phe). About 120 adults will take either JNT-517 or a placebo for 6 weeks, then all will receive JNT-517 for nearly a year. The goa…

This study tests the long-term safety of an experimental drug called JNT-517 in children and adults with PKU, a genetic condition that causes harmful buildup of phenylalanine. All 240 participants will receive the drug, and researchers will monitor side effects and changes in blo…

This early-stage trial tests a new drug called VIS171 in 30 people with autoimmune diseases like lupus, alopecia areata, or a kidney condition. The main goal is to check if the drug is safe and tolerable when given as a shot under the skin. Participants will be followed for up to…

This study tests the safety of a drug called tolvaptan in children (28 days to under 18 years) with autosomal recessive polycystic kidney disease (ARPKD), a rare genetic condition that causes kidney cysts. About 20 participants will take the drug for 18 months to see if it helps …

This study tests a new medication called Ulotaront (SEP-363856) to see if it can safely reduce severe symptoms like hallucinations and delusions in people with schizophrenia. About 522 adults experiencing an acute psychotic episode will receive either the drug or a placebo for 6 …

This early-stage study tests how well the experimental drug MSP-2020 attaches to serotonin receptors in the brains of 18 healthy men. Researchers will measure drug levels in the blood and check for side effects. The goal is to understand how the drug works in the body before test…

This study tests how a new drug called repinatrabit interacts with other common medications like birth control pills, metformin, and methotrexate. It involves 48 healthy adults and aims to measure drug levels in the blood. The results will help guide safe use of repinatrabit in f…