New pill could help control PKU without strict diet
NCT ID NCT06971731
First seen Jan 05, 2026 · Last updated May 14, 2026 · Updated 23 times
Summary
This study tests an oral drug called JNT-517 for adults with phenylketonuria (PKU), a genetic condition that causes harmful buildup of phenylalanine (Phe). About 120 adults will take either JNT-517 or a placebo for 6 weeks, then all will receive JNT-517 for nearly a year. The goal is to see if the drug safely lowers blood Phe levels, which may help manage the disease long-term.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Beatrix Children's Hospital
RECRUITINGGroningen, Netherlands
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Centre Hospitalier Régional Universitaire (CHRU) de Tours - Hôpital Bretonneau
RECRUITINGTours, France
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Fakultní nemocnice Královské Vinohrady
RECRUITINGPrague, Czechia
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Fujita Health University
RECRUITINGKutsukake-cho, Japan
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Hospital Clinico Universitario de Santiago de Compostela
RECRUITINGSantiago de Compostela, Spain
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Hospital Universitario Ramón y Cajal
RECRUITINGMadrid, Spain
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M.A.G.I.C Clinic
RECRUITINGCalgary, Alberta, T2E 7H7, Canada
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Mater Health - Mater Hospital Brisbane
RECRUITINGSouth Brisbane, 4104, Australia
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Nihon University Hospital
RECRUITINGChiyoda-ku, Japan
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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Osaka Metropolitan University Hospital
RECRUITINGOsaka, Japan
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Pomorski Uniwersytet Medyczny w Szczecinie
RECRUITINGSzczecin, Poland
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Royal Adelaide Hospital
RECRUITINGAdelaide, 5000, Australia
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Royal Melbourne Hospital
RECRUITINGParkville, Australia
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Universitair Medisch Centra (AMC)- Amsterdam
RECRUITINGAmsterdam, Netherlands
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University of California Los Angeles (UCLA) School of Medicine
RECRUITINGLos Angeles, California, 90024, United States
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University of Florida (UF) Health Shands Hospital
RECRUITINGGainesville, Florida, 32608, United States
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University of Pittsburgh Medical Center (UPMC) - Children's Hospital of Pittsburgh
RECRUITINGPittsburgh, Pennsylvania, 15201, United States
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University of South Florida
RECRUITINGTampa, Florida, 33606, United States
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University of Texas Health (UTHealth) Science Center at Houston
RECRUITINGHouston, Texas, 77030-1501, United States
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University of Texas Southwestern
RECRUITINGDallas, Texas, 75390, United States
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Universitätsklinikum Münster
RECRUITINGMünster, Germany
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Utah Health - The University of Utah Hospital
RECRUITINGSalt Lake City, Utah, 84112, United States
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
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Conditions
Explore the condition pages connected to this study.