New pill could help control PKU – phase 3 trial now recruiting

NCT ID NCT06971731

Recruiting now Disease control Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This study tests an experimental oral drug, JNT-517, for adults with phenylketonuria (PKU), a genetic condition that causes harmful buildup of phenylalanine (Phe). About 120 adults will receive either JNT-517 or a placebo for 6 weeks, then all will receive JNT-517 for nearly a year. The goal is to see if the drug safely lowers blood Phe levels and helps manage the disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

phenylketonuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PHENYLKETONURIA

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Beatrix Children's Hospital
RECRUITING

Groningen, Netherlands
Centre Hospitalier Régional Universitaire (CHRU) de Tours - Hôpital Bretonneau
RECRUITING

Tours, France
Fakultní nemocnice Královské Vinohrady
RECRUITING

Prague, Czechia
Fujita Health University
RECRUITING

Kutsukake-cho, Japan
Hospital Clinico Universitario de Santiago de Compostela
RECRUITING

Santiago de Compostela, Spain
Hospital Universitario Ramón y Cajal
RECRUITING

Madrid, Spain
M.A.G.I.C Clinic
RECRUITING

Calgary, Alberta, T2E 7H7, Canada
Mater Health - Mater Hospital Brisbane
RECRUITING

South Brisbane, 4104, Australia
Nihon University Hospital
RECRUITING

Chiyoda-ku, Japan
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Osaka Metropolitan University Hospital
RECRUITING

Osaka, Japan
Pomorski Uniwersytet Medyczny w Szczecinie
RECRUITING

Szczecin, Poland
Royal Adelaide Hospital
RECRUITING

Adelaide, 5000, Australia
Royal Melbourne Hospital
RECRUITING

Parkville, Australia
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz
RECRUITING

Mainz, Germany
Universitair Medisch Centra (AMC)- Amsterdam
RECRUITING

Amsterdam, Netherlands
University of California Los Angeles (UCLA) School of Medicine
RECRUITING

Los Angeles, California, 90024, United States
University of Florida (UF) Health Shands Hospital
RECRUITING

Gainesville, Florida, 32608, United States
University of Pittsburgh Medical Center (UPMC) - Children's Hospital of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15201, United States
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
University of Texas Health (UTHealth) Science Center at Houston
RECRUITING

Houston, Texas, 77030-1501, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States
Universitätsklinikum Münster
RECRUITING

Münster, Germany
Utah Health - The University of Utah Hospital
RECRUITING

Salt Lake City, Utah, 84112, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.