Otsuka Pharmaceutical Development & Commercialization, Inc.

This study aimed to test an experimental drug called OPC-131461 in people hospitalized with worsening heart failure who still had fluid buildup after initial treatment. The goal was to see if the drug could improve a key heart stress marker over 30 days compared to a placebo. How…

This study tests a new medicine called sibeprenlimab for people with Sjögren's disease, a condition that causes dry eyes, dry mouth, and joint pain. About 83 adults will receive either the drug or a placebo as an add-on to their current treatments. The goal is to see if the drug …

This study tests the long-term safety and effectiveness of sibeprenlimab, an experimental drug, in about 600 adults with IgA nephropathy—a kidney disease that can lead to kidney failure. Participants must have completed a prior sibeprenlimab study and may benefit from continued t…

This study tests a drug called sibeprenlimab in 530 adults with IgA nephropathy, a kidney disease that can lead to kidney failure. The goal is to see if the drug can reduce protein in the urine and slow the loss of kidney function over time. Participants receive either the drug o…

This study planned to test the drug tolvaptan in very young infants (28 days to under 12 weeks old) with a rare, severe kidney disease called ARPKD. The goal was to see if the drug could reduce the need for dialysis or a kidney transplant in the first year of life. However, the s…