Ono Pharmaceutical Co. Ltd

This study is testing an investigational drug called ONO-4059 for people with pemphigus, a serious autoimmune disease that causes painful skin blisters, when standard steroid treatment has failed. About 34 participants will be randomly assigned to receive either the new drug plus…

This early-stage study is testing a new drug called ONO-7428 in people with advanced solid tumors that cannot be surgically removed or have returned after treatment. The main goal is to find the highest dose that patients can tolerate safely and understand how the drug behaves in…

This study is testing whether adding two new immunotherapy drugs (ONO-4578 and Opdivo®) to standard chemotherapy works better than standard care alone for people with a specific type of advanced colorectal cancer. It will involve about 144 adults who have not yet received treatme…

This early-stage study is testing a new drug called ONO-4685 in people with T cell lymphoma that has returned or hasn't responded to previous treatments. Researchers will give increasing doses to 217 participants to find the safest amount and see how the body processes the drug. …

This study is testing an experimental drug called ONO4538 in patients with advanced or recurrent rhabdoid tumors, a rare and aggressive cancer. It is for people aged 1 year and older whose cancer has not responded to or has come back after standard chemotherapy. The main goal is …

This study is testing whether a new oral drug called tirabrutinib works better than the current standard combination therapy (rituximab and temozolomide) for people whose primary brain lymphoma has come back or didn't respond to prior treatment. It will involve about 132 particip…

This study is testing whether an experimental drug called ONO-4538 can help control Richter's transformation, an aggressive cancer that develops in some patients with chronic lymphocytic leukemia. The trial will enroll 14 patients who have already tried other treatments without s…

This study is testing an investigational drug called ONO-1110 to see if it can safely reduce pain and improve urinary symptoms in people with a specific, painful type of chronic bladder inflammation. About 50 Japanese adults with this condition will receive either the drug or a p…

This study is testing whether an investigational medicine called ONO-2020 can safely reduce agitation in people with Alzheimer's disease dementia. It will involve about 90 patients in Japan who will be randomly assigned to receive either the drug or a placebo while hospitalized. …

This early-stage study aims to understand how a drug called tirabrutinib, used for a type of brain lymphoma, is processed by the body in people with different levels of liver damage. It will compare 32 participants—some with mild, moderate, or severe liver impairment and some hea…