Institut Für Klinische Krebsforschung Ikf Gmbh At Krankenhaus Nordwest

This study is testing whether combining two immunotherapy drugs (durvalumab and tremelimumab) with a targeted internal radiation treatment (Y-90 SIRT) is safe and effective for people with intermediate-stage liver cancer that cannot be removed by surgery. The goal is to see if th…

This study is testing whether combining the drugs fruquintinib and tislelizumab works better than standard therapy for people with a common, hard-to-treat type of advanced colorectal cancer that hasn't spread to the liver. About 140 participants will be randomly assigned to recei…

This study is observing whether a procedure called TIPS, which creates a shunt to relieve pressure in the liver, helps patients with advanced liver cancer. The goal is to see if this procedure allows patients to better tolerate and potentially get more benefit from their standard…

This study is testing whether a drug called ivosidenib can help prevent cancer from returning in people with a specific type of bile duct cancer who have already had surgery and chemotherapy. The trial will involve about 40 patients who have a particular genetic mutation (IDH1) i…

This early-stage trial is testing whether combining a newer immunotherapy drug (tislelizumab) with standard chemotherapy (FLOT) is safe and tolerable when given before surgery for certain stomach and esophagus cancers. The goal is to see if giving more chemotherapy before surgery…

This study is testing whether the immunotherapy drug cemiplimab works as a first treatment for advanced basal cell carcinoma, a type of skin cancer that can't be removed with surgery or radiation. The trial will enroll 34 adults with this advanced cancer who haven't tried other t…

This study is testing whether new combinations of cancer drugs are safe and effective when given before surgery for a specific type of advanced stomach or esophageal cancer. The trial will involve about 36 patients whose cancer has a specific marker called HER2-positive. The goal…

This study is testing a new three-drug combination for people with advanced stomach or esophageal cancer that has spread. It's for patients who have not yet received treatment for their advanced cancer and whose tumors test positive for two specific markers (HER2 and PD-L1). The …

This study is testing whether combining two treatments works better for advanced bile duct cancer that cannot be removed by surgery. Doctors will use a small device to heat and destroy tumor cells inside the bile duct, followed by an immunotherapy drug (durvalumab) plus standard …

This trial is testing a new three-part treatment for people with advanced colorectal cancer that cannot be surgically removed. It combines a standard chemotherapy, an immunotherapy drug (tislelizumab), and an experimental targeted drug (futibatinib). The main goal is to see how w…

This study is testing a new combination of two existing drugs, enfortumab vedotin and avelumab, as a first treatment for men with advanced penile cancer that has spread or cannot be removed by surgery. The main goal is to see how well the combination shrinks tumors and controls t…

This study is creating a large national registry to collect information about sarcoma, a rare type of cancer, and related tumors in Germany. It aims to enroll up to 9,000 adult patients to better understand how these cancers are currently treated and what outcomes patients experi…