Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study looks at how well the drug daratumumab works for people with a rare blood clotting condition called immune-mediated thrombotic thrombocytopenic purpura (iTTP) who did not get better with standard treatments. Researchers will track 40 patients from multiple countries to…

This study looks at whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have stomach issues like bloating and constipation. About 150 women will either follow the diet or continue their usual care. The goal is to see if chang…

This study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…

This study uses tiny, lab-grown liver models (organoids) made from patient cells to understand how a specific gene variant (I148M of PNPLA3) contributes to non-alcoholic steatohepatitis (NASH), a serious fatty liver disease. Researchers will expose these mini-livers to fatty acid…

This study looks at how genetic factors influence the risk of liver damage and heart problems in people with fatty liver disease. Researchers will enroll 2,500 blood donors aged 40-65 who are overweight or have related conditions like high blood sugar or high cholesterol. The goa…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study looks at how the immune system reacts to hepatitis D virus in people who also have hepatitis B. Researchers will measure immune cell activity in 192 adults before and during treatment with the drug bulevirtide. The goal is to learn why some patients get worse faster an…

This study looks at whether using a mix of brain scans, spinal fluid tests, and thinking/movement assessments can better diagnose idiopathic normal pressure hydrocephalus (iNPH) and identify who will benefit from shunt surgery. Researchers will follow 116 adults aged 60+ with sus…

This study aims to create a rapid blood test that measures T-cell responses in people with chronic hepatitis B (HBV) or combined hepatitis B and D (HBV/HDV). Researchers will enroll 300 adults to see how these immune responses relate to disease severity and treatment outcomes. Th…

This study looks at whether blocking two specific gene regulators in the liver can protect against nonalcoholic fatty liver disease (NAFLD). Researchers will test this in mice, analyze human genetic data, and use lab-grown mini-livers. The goal is to find new treatment targets fo…

This study aims to see if a special cell culture system can detect a substance in the blood that causes protein leakage in the urine of people with a kidney condition called nephrotic syndrome. Researchers will compare blood and urine samples from 150 participants, including pati…