Dana-farber Cancer Institute

This study tests a drug called cosibelimab in 80 people with advanced skin cancer who also have a kidney transplant or a blood cancer. The goal is to see if the drug is safe and shrinks tumors. Participants receive the drug by IV and are monitored for side effects and response.

This study tests whether using a blood test that detects HPV DNA can help doctors choose the right level of treatment for people with HPV-positive throat cancer. About 116 participants with early-stage cancer will receive therapy tailored to their risk, based on blood results and…

This study tests a program to help women with ER-positive breast cancer in Rwanda take their daily hormone therapy pills as prescribed. The program includes education, reminders, and support. Researchers will check if it improves how well patients follow their treatment plan over…

This study tests a new combination of chemotherapy and immunotherapy drugs for adolescents and young adults (ages 15-39) with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL). The goal is to see if this treatment plan helps more patients complet…

This study is for people newly diagnosed with multiple myeloma who cannot have or choose not to have a stem cell transplant. Researchers are testing a combination of four drugs (isatuximab, iberdomide, bortezomib, and dexamethasone) to find the safest dose and see how well it con…

This study tests an experimental drug called FHD-286 in people with a specific type of small-cell lung cancer that has a marker called POU2F3. Participants must have already tried at least one standard chemotherapy. The drug is taken daily in 3-week cycles, and researchers will m…

This study compares two low-dose hormone drugs, exemestane and tamoxifen, in 140 postmenopausal women at high risk for breast cancer. The goal is to see which drug causes fewer menopausal symptoms while still helping to prevent breast cancer. Participants will take the assigned d…

This study tests a smartphone app called I-STAMP designed to help people with advanced cancer manage their pain and keep track of their medications. About 73 participants will use the app and then rate how easy it is to use and how helpful they find it. The goal is to see if the …

This study tests whether a personalized exercise program is practical for 20 adults with stage II or III non-small cell lung cancer before they start treatment. Participants will follow the Precise Exercise Regimen for Cancer Care (PERCC) program, and researchers will measure how…

This study tests an educational program called SHARE-MC designed to help women with metastatic breast cancer address sexual health concerns. Researchers will enroll 96 women who report significant sexual dysfunction. The program aims to improve sexual function and reduce psycholo…

This study is testing a new web and mobile app called SHIELD, designed to help women with hormone-receptor-positive breast cancer who are on long-term endocrine therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women aged 18-49 wil…

This study tests whether adding acupuncture to virtual exercise can reduce nerve pain caused by chemotherapy in people with advanced bladder cancer. About 50 participants will either do acupuncture plus virtual exercise or just virtual exercise. The goal is to see if this combina…

This study aims to create a personalized nutrition program called NACHO for people who are going through or have finished cancer treatment. Researchers will work with dietitians, patients, and advisors to build a computer tool that suggests the best foods for each person. The goa…

This study is building an AI tool called ACTIVATE that uses electronic health records to find which cancer patients might be eligible for clinical trials. Researchers will test the tool on data from up to 70,000 adults with cancer. The goal is to make it easier and faster to matc…