Children's Hospital Of Fudan University

This study tests whether hydroxychloroquine, a medicine used for malaria and autoimmune conditions, can safely improve breathing in children with a rare genetic lung disease. About 60 children under 18 with a confirmed genetic cause will receive either the drug or a placebo. The …

This study looks at whether a machine called ECMO can help children with severe septic shock who are not getting better with standard treatment. ECMO works as an artificial heart and lung to support the body. The study will include 60 children and aims to see if ECMO improves sur…

This study looks at whether probiotics and prebiotics can safely help control appetite and weight gain in 60 children with Prader-Willi syndrome, a rare genetic condition that causes severe obesity. The children will take the supplements and be monitored for changes in body mass …

This study looks at whether a special diet high in medium-chain triglycerides (a type of fat that is easier to digest) can help infants with biliary atresia grow better after their Kasai surgery. About 300 babies under 3 months old who had the surgery will be followed to see how …

This study tests whether a combination of Chinese herbs and tiny acupuncture needles can help girls with early puberty. About 170 girls aged 7.5 or younger will receive either the treatment or a placebo for six months. The goal is to see if the treatment can shrink breast tissue …

This study looks at two types of blood filters (membranes) used in a treatment called continuous blood purification for children with sepsis. Sepsis causes a dangerous overreaction in the body that can damage organs. The filters help remove harmful substances from the blood. The …

This study looks at whether a bundle of developmental care practices can help very low birth weight infants (under 1500 grams) spend less time in the hospital and receive more family-centered care. About 1600 babies across 40 neonatal intensive care units will take part. The care…

This study looks at whether a substance in the blood called FGF19, measured before surgery, can help predict how well children with biliary atresia will do after their operation. Researchers will follow 200 children for one year to see if FGF19 levels are linked to liver function…

This study looks at the genes of 2000 newborns and infants who have seizures within their first year of life. Researchers want to find which gene changes are common and how they affect treatment. The goal is to use this information to choose more effective, personalized treatment…

This study aims to find kidney disease early in children by testing their urine and doing ultrasound scans. About 13,000 children from China will take part, and those with abnormal results will be referred for further care. The goal is to better understand how common kidney probl…

This study aims to improve how nurses place feeding tubes in hospitalized children. Researchers will review the latest evidence, identify gaps in current practices, and train nurses on the safest methods. The goal is to reduce complications and ensure children receive nutrition s…

This study looks back at the last 10 years to understand how ECMO—a machine that helps the heart and lungs work—has been used in children across mainland China. Researchers will review records from 500 children, from newborns to 18-year-olds, to see survival rates, how long treat…

This study looks at how the antibiotic ceftazidime avibactam behaves in children with severe infections who are on life support. Researchers will measure drug levels and how the body processes it. The goal is to find the best dosing to improve treatment for sepsis. About 30 child…

This study is testing whether advanced genetic sequencing can help doctors quickly diagnose birth defects and genetic diseases in newborns in intensive care. By analyzing the DNA of 2000 babies, researchers hope to shorten diagnosis time, improve detection rates, and guide person…

This study uses a special brain scanner called magnetoencephalography (MEG) to measure brain activity in children with conditions like epilepsy, autism, ADHD, and brain tumors. Researchers will compare these signals with those from healthy children to improve diagnosis. The study…

This study watches how helping behaviors and brain connections grow in 100 infants with a higher or lower chance of developing autism. Researchers use play-based tests and brain scans (EEG, MRI) while babies sleep naturally. The goal is to spot early differences that may lead to …