Centre Hospitalier Universitaire Vaudois

This study compares two surgical methods for repairing large cartilage defects in the knee: augmented microfracture (AMT) and matrix-assisted chondrocyte implantation (MACT). It will enroll 80 people aged 15-50 with symptomatic defects. The goal is to see which technique better i…

This study tests whether giving scheduled morphine alongside patient-controlled pain relief can prevent the intense 'rebound pain' that often occurs when a nerve block wears off after orthopaedic surgery. About 100 adults having arm or leg surgery will be randomly assigned to rec…

This study tests whether giving scheduled morphine doses alongside on-demand pain relief can prevent the severe 'rebound pain' that often occurs when a nerve block wears off after orthopedic surgery. One hundred adults having arm or leg surgery will be randomly assigned to receiv…

This study looks at people who have both sleep apnea and chronic insomnia. All 120 participants will receive standard CPAP therapy for sleep apnea. Half will also get a digital program to treat their insomnia starting at the same time as CPAP. The other half will follow usual car…

This study compares two ways to manage pain after a second hip replacement. One group gets a PENG block (a targeted injection around the hip joint), while the other gets a combination of blocks around the thigh and hip. Both use the same numbing medicine. The goal is to see which…

This study looks for VEXAS syndrome, a recently discovered genetic condition, in adults over 50 who are hospitalized with unexplained fever, inflammation, or blood abnormalities. Researchers will screen participants using clinical exams and genetic testing of the UBA1 gene. The g…

This study tests whether injecting two dyes around the tumor and into cancerous lymph nodes can help surgeons spot hidden cancer spread in head and neck cancer. Twenty adults with oral cavity or head and neck skin cancer will receive the dyes before surgery. The goal is to see if…

This study will give 50 adults a smart device to wear before and after non-cardiac surgery. The goal is to see if data from the device can help doctors spot complications earlier. Participants will also answer health questionnaires. The study is observational, meaning no treatmen…

This study tests a special filter (Jafron HA-60) used during heart-lung bypass in 20 children having open-heart surgery. The filter is designed to remove inflammatory substances from the blood, which may help reduce complications. The main goal is to see if using the filter is sa…