Centre Hospitalier Universitaire De Besancon

This study tests whether adding a cancer vaccine (UCPVax), with or without an immunotherapy drug (pembrolizumab), to standard treatment can help people with a fast-growing type of brain cancer (glioblastoma) live longer. About 98 adults with newly diagnosed glioblastoma that has …

This study looks at whether giving a drug called dapagliflozin (a gliflozin) early to elderly patients (75 and older) with worsening heart failure in the emergency room is practical. About 144 participants will either get the drug within 24 hours plus a follow-up call, or standar…

This study looks at whether doing an early belly ultrasound can help doctors diagnose serious digestive problems in premature babies. About 100 premature infants with symptoms like bloating, bleeding, or vomiting will get an early ultrasound. The goal is to see if this test, alon…

This study looks at whether adding real-time weather and air pollution information to a standard checklist can help emergency room doctors identify acute aortic syndrome (a life-threatening tear in the main artery) more accurately. Researchers will review medical records and envi…

This study tests whether a saliva sample can find genetic causes of neurodevelopmental disorders that standard blood tests miss. Researchers will use advanced DNA sequencing on cheek swabs from 50 people with intellectual or developmental disabilities. The goal is to improve diag…

This study looks at whether a special ultrasound technique (VEXUS) can help doctors see when ICU patients have too much fluid in their veins, a condition called venous congestion. The goal is to better guide fluid treatment and avoid harm. About 525 adults in intensive care will …

This study looks at how well the DPD enzyme works in people with cancer and/or kidney failure. The DPD enzyme breaks down common chemotherapy drugs, and low activity can cause severe side effects. Doctors currently use a blood test to check DPD function, but kidney problems may m…

This study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare the exercise group to a group doing a non-exercise activity. The goal is to understand the link betw…