Centre Hospitalier Universitaire De Besancon

This study looks at whether starting the drug dapagliflozin within 24 hours of arriving at the emergency room is practical for elderly patients (75+) with acute heart failure. It will involve 144 patients across 6 hospitals, comparing early drug treatment plus a nurse phone call …

This phase 2 trial tests whether adding a cancer vaccine (UCPVax) with or without an immunotherapy drug (pembrolizumab) to standard treatment can help people with a newly diagnosed, aggressive type of glioblastoma live longer. About 98 adults whose tumors have a specific genetic …

This study tests whether a simple saliva swab can find genetic causes of neurodevelopmental or intellectual disorders when standard blood tests have not. Researchers will use advanced DNA sequencing on cheek cells from 50 participants. The goal is to improve diagnosis and help gu…

This study looks at whether adding real-time weather and air pollution data to a standard clinical score can help emergency doctors spot acute aortic syndrome (a life-threatening tear in the main artery) more accurately. Researchers will review medical records and environmental d…

This study will test whether doing an early abdominal ultrasound helps doctors diagnose serious stomach problems in premature newborns. The researchers will look for specific ultrasound signs in 100 premature babies with symptoms like bloating, bleeding, or vomiting. The goal is …

This study will test whether a cone-beam CT scanner can create 3D wrist models as good as the current standard CT scan, but with less radiation and faster processing. Six healthy volunteers will get both scans a few weeks apart. The goal is to see if the new method is accurate en…

This study will use a bedside ultrasound technique called VExUS to measure vein congestion in 525 intensive care patients. The goal is to see how common congestion is and whether the scan is feasible, even in patients lying on their stomachs. The results may help doctors give flu…

This study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare exercise to a non-physical activity in 52 women. The goal is to understand the link between depressi…

This study looks at whether kidney problems interfere with a common blood test used to check how well patients break down certain chemotherapy drugs (fluoropyrimidines). Researchers will measure DPD enzyme activity in about 742 people with breast or digestive cancer, kidney failu…