Experimental vaccine aims to boost immune attack on glioblastoma
NCT ID NCT07347210
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding a cancer vaccine (UCPVax) with or without an immunotherapy drug (pembrolizumab) to standard treatment can help people with a newly diagnosed, aggressive type of glioblastoma live longer. About 98 adults whose tumors have a specific genetic marker (unmethylated MGMT) will be randomly assigned to one of three groups. The study will measure how many are alive after 18 months and look for immune changes in the tumor.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- UCPVax (a cancer vaccine targeting telomerase) with or without pembrolizumab (an immunotherapy drug), plus temozolomide (chemotherapy) and optional tumor-treating fields
- What this could lead to
- If successful, this combination could extend survival for people with a hard-to-treat brain cancer (glioblastoma) by helping the immune system fight the tumor more effectively.
- What could go wrong
- This is an early phase 2 trial with only 98 participants, so results may not apply to all patients. The vaccine and immunotherapy can cause immune-related side effects, and the overall benefit is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU La Timone
Marseille, France
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CHU de Besançon
Besançon, France
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Centre Georges François Leclerc
Dijon, France
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Hôpital Saint-Louis - APHP
Paris, France
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