Aids Malignancy Consortium

This study tested whether nelfinavir, a drug originally used for HIV, can shrink Kaposi sarcoma tumors in the skin. 36 adults with Kaposi sarcoma (some HIV-positive, some HIV-negative) took the drug to see if it stopped cancer cell growth. The goal was to measure how many people …

This study tested a drug called pomalidomide in 26 HIV-positive people with Kaposi sarcoma, a type of skin cancer. The drug works by boosting the immune system and blocking blood vessel growth to tumors. The goal was to see if it could shrink tumors and how safe it was. The trial…

This study tested whether the HPV vaccine can reduce high-grade cervical lesions (precancerous growths) in women living with HIV. About 536 women received either the HPV vaccine or a placebo, and researchers tracked how many developed serious cervical changes over one to two year…

This study tested a DNA-based vaccine called VGX-3100 in 44 HIV-positive adults with high-grade anal precancer caused by HPV types 16 or 18. The vaccine was given with a mild electric pulse (electroporation) to help cells absorb it and boost the immune system's attack on the abno…

This study tested a drug called sEphB4-HSA in 23 people with Kaposi sarcoma, a type of skin cancer. The drug works by blocking the growth of blood vessels that feed the cancer and may also stop cancer cells from growing. The main goal was to see how many patients had a clinical r…

This study looked at whether removing small, early-stage anal cancers with local surgery alone is safe and effective for people with HIV. The goal was to see if this less invasive approach could avoid the need for stronger treatments like radiation or chemotherapy. Sixteen partic…

This study looked at 460 people with HIV who came to cancer clinics across the U.S. to find out what types of cancer they had and why some chose to join cancer clinical trials. Researchers counted new and existing cancer cases and compared them to national data. The goal was to b…

This study looked back at 30 people with HIV who had already received a special cancer treatment called CAR T-cell therapy for certain blood cancers like leukemia or lymphoma. Researchers collected information from their medical records to see what side effects occurred and how t…

This study followed 10 people with HIV and AIDS-related Kaposi sarcoma in Tanzania to see how their quality of life changed during treatment with vincristine and bleomycin. Participants filled out questionnaires about their physical, emotional, social, and daily functioning over …