TESTICULAR CANCER

This study tests a drug called tarlatamab (AMG 757) given together with radiation therapy for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and brain tumors. The goal is to see if the combination is safe and helps shrink tumors. About 30 adults…

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancers that have come back or are hard to treat. The drug is designed to help the body's immune cells attack cancer cells that have a specific marker (CLDN6). The main goals…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety in a small group of 10 patients. It is not a cure, but …

This study looks at how well the drug T-DXd works for adults with advanced HER2-positive solid tumors who have already tried other treatments and have no good alternatives. About 100 people will take T-DXd as part of their regular care, and researchers will track tumor shrinkage …

This study tests whether a daily low-dose aspirin can prevent dangerous blood clots in people with advanced germ cell tumors (including testicular cancer) who are receiving standard chemotherapy. About 35 participants will take aspirin alongside their chemo for 26 weeks. The goal…

This study tests a drug called Pedmark (sodium thiosulfate) to see if it can prevent hearing loss in adults receiving cisplatin chemotherapy for cancers like testicular, head and neck, or thoracic cancer. About 25 adults will take Pedmark alongside their chemo. The drug is alread…

This study tests a digital program called AYA STEPS for adolescent and young adult cancer survivors. The program helps manage symptoms like pain, fatigue, and emotional distress, and encourages engagement with recommended follow-up care. About 260 participants who have completed …

This study tests a digital program that pairs young adults (ages 18-40) who have finished cancer treatment with trained peer navigators. The goal is to help them feel more in control of their health and overcome challenges like stress, financial strain, and interrupted life goals…

This study compares two standard pain relief methods—morphine given via a spinal injection and methadone given through an IV—for men undergoing testicular cancer surgery. The goal is to see which approach provides better pain control and reduces the need for additional opioids. A…

This study looks at two common surgical methods for removing a testicle due to cancer. The goal is to see if one technique causes less pain, less need for painkillers, and fewer nerve-related issues after surgery. About 80 adults with suspected testicular cancer will take part, a…

This study tests whether brodalumab, a drug used for autoimmune diseases, can safely reduce side effects caused by cancer immunotherapy. About 11 adults with various cancers who have developed immune-related side effects will receive brodalumab. The goal is to see if it can lower…

This study is creating a large, long-term database of medical information and biological samples from people with many types of cancer, those at high risk, and healthy volunteers. Researchers will use this resource to study what causes cancer, how it progresses, and how to better…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study follows 160 men with good-prognosis metastatic testicular cancer to see if surgery (RPLND) causes fewer side effects than chemotherapy. Participants choose either surgery or chemo, and researchers track their quality of life and fatigue over time. The goal is to find w…