SYSTEMIC SCLERODERMA

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This early study is testing a new treatment called CD19 CAR-T therapy for people with severe autoimmune diseases like lupus and scleroderma that haven't improved with standard medications. The therapy involves taking a patient's own immune cells, reprogramming them to target and …

This early study tests whether a precise type of total body radiation (IMRT) combined with chemotherapy can safely prepare the body for a stem cell transplant in people with severe systemic sclerosis (scleroderma). The goal is to reduce radiation exposure to the lungs and kidneys…

This study looks at skin cells called fibroblasts from people with scleroderma and healthy volunteers. Researchers want to find which genes are turned on or off in these cells, especially those linked to aging and inflammation. The goal is to better understand what causes the dis…

This study looks at 20 adults with systemic scleroderma who have a family history of the disease. Researchers will describe their symptoms and progression to find clues about how the disease works and identify markers that could lead to new treatments. The goal is to learn more, …

This study is testing a new, non-invasive imaging technique called spatial frequency domain imaging (SFDI) to measure skin thickness in people with scleroderma. Currently, doctors use a subjective pinch test, but SFDI uses light scattering to measure collagen in the skin more acc…