SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

This early-stage study tests whether a single infusion of a patient's own modified immune cells (CAR-T cells) is safe for people with severe autoimmune diseases like lupus, rheumatoid arthritis, or scleroderma that haven't improved with standard treatments. Only 6 adults aged 18-…

This study tests a new medicine, SCTC21C, in 159 adults with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The goal is to see if the drug is safe and can reduce lupus symptoms. Participants must be on stable standard treatments and will receive the study drug …

This study looks at whether a Mediterranean diet can improve gut health, reduce disease activity, and boost nutrition in children with lupus. About 60 children with lupus and their healthy family members will take part. For 12 weeks, some children will get personalized nutrition …

This study tests a new treatment called BCMA-CD19-IL-15 cCAR T cells for people with severe lupus that hasn't responded to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to attack lupus-causing cells. The goal is to see if it is safe and ca…

This early-stage study tests a new medicine called HC022 in 32 adults with lupus (SLE or CLE). The main goal is to see if the drug is safe and how the body handles it. Participants will receive multiple doses or a placebo, and researchers will monitor for side effects and measure…

This early-stage study will test a new cell therapy called YTS109 in 12 children aged 5 to 18 with severe autoimmune diseases like lupus and scleroderma that haven't responded to other treatments. The therapy is given as a single IV infusion, and the main goals are to see if it i…

This study follows 700 adults recently diagnosed with lupus across Europe for up to 5 years. Researchers will track symptoms, treatment, and quality of life, and collect blood and urine samples. The goal is to understand how lupus develops early on and find markers that predict w…

This study looks at 400 people with lupus to compare those with typical symptoms (like joint pain and rash) to those with unusual or late-onset symptoms. The goal is to see if atypical forms lead to more organ damage or different treatment needs. Researchers will track disease ac…

This study looks at two substances in the blood—microRNA-101-3p and autotaxin—in 40 adults with lupus and 40 healthy volunteers. Researchers want to see if these markers are different in people with lupus and if they are linked to how active the disease is. No treatments or drugs…

This study looks at how common and severe gum disease is in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus with kidney involvement. Researchers will compare them to people with chronic kidney disease and healthy vol…