STARGARDT DISEASE

This study tests an investigational drug called gildeuretinol acetate (ALK 001) in 230 people aged 8 to 45 with Stargardt disease, an inherited condition that causes progressive vision loss. The goal is to see if the drug can slow the growth of damage in the retina and help prese…

This early-stage study tests the safety of a single injection of RTx-021 into the eye for people with Stargardt disease, a genetic condition that causes vision loss. Up to 18 participants aged 16 and older will receive the injection and be monitored for 5 years. The main goal is …

This study tests whether the diabetes drug metformin is safe and can slow vision loss in people with ABCA4 retinopathy (Stargardt disease), a genetic condition that causes progressive blindness. About 56 participants aged 12 and older will take metformin daily for 24 months, with…

This study tests a device called PRIMA, which is implanted in the eye to help restore central vision in people with inherited retinal diseases like Stargardt disease and retinitis pigmentosa. Five adults with severe vision loss will receive the implant and be monitored for improv…

This early-stage study tests a single injection of ACDN-01 into the eye for people with Stargardt disease or cone-rod dystrophy caused by ABCA4 gene mutations. The main goals are to check safety and find the best dose. About 15 adults with advanced vision loss will take part. The…

This study tests a one-time gene therapy injection (AAVB-039) into the eye for people with Stargardt disease, a genetic condition that causes progressive vision loss. The trial involves 75 participants and will first check safety, then measure if the treatment can slow damage to …

This early study tests whether disulfiram (Antabuse), a drug used for alcohol use disorder, can improve eyesight in people with retinal degeneration (like macular degeneration or retinitis pigmentosa). Researchers believe it may calm overactive cells in the retina. The study invo…

This study follows children (over 6) and adults with Stargardt disease or similar inherited eye conditions to see how their vision changes over 2 years. Participants get standard eye tests every 6 months, but no new treatment is given. The goal is to better understand how these d…

This study is for people with retinal diseases like retinitis pigmentosa or Stargardt disease who have low vision. Researchers want to see if certain vision tests can be done reliably by these patients. The goal is to develop better ways to measure vision in future clinical trial…

This study is a pre-screening step for people with Stargardt disease or cone-rod dystrophy caused by ABCA4 gene mutations. It uses genetic tests and eye exams to see who may qualify for upcoming ACDN-01 clinical trials. About 50 participants will be enrolled to confirm their diag…

This early-stage study tests the safety of an experimental oral drug called DC6001 in 76 healthy adults aged 18-55. It does not aim to treat or cure Stargardt disease directly, but to gather important information on how the drug behaves in the body and whether it is safe. Partici…

This study follows 75 people aged 12 to 65 with Stargardt disease type 1, a genetic eye condition that causes vision loss. Researchers will measure changes in the retina and eyesight over time using special imaging and vision tests. The goal is to better understand how the diseas…