STAGE IV RENAL CELL CANCER AJCC V8
Clinical trials for STAGE IV RENAL CELL CANCER AJCC V8 explained in plain language.
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Cold sore virus turned against kidney cancer in new combo trial
Disease control Not yet recruitingThis study tests a new combination for people with advanced kidney cancer that has spread and is no longer responding to immunotherapy. The treatment uses a modified cold sore virus (RP2) to infect and destroy cancer cells while also activating the immune system, plus a drug call…
Matched conditions: STAGE IV RENAL CELL CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 15, 2026 19:02 UTC
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Could a cheaper, Lower-Dose immunotherapy work just as well for advanced cancers?
Disease control Not yet recruitingThis study tests whether giving a lower dose of the immunotherapy drug nivolumab less often can still control advanced cancers that have spread or cannot be removed. About 50 adults with various cancers (like melanoma, lung, or kidney cancer) will receive the treatment. The goal …
Matched conditions: STAGE IV RENAL CELL CANCER AJCC V8
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 15, 2026 18:56 UTC
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New combo aims to reignite immune attack on kidney cancer
Disease control Not yet recruitingThis study tests a new drug combination for people with advanced kidney cancer that has spread and worsened after immunotherapy. The drugs are zanzalintinib (which blocks cancer growth) and MO-03 (a gut bacteria supplement that may help the main drug work better). About 34 adults…
Matched conditions: STAGE IV RENAL CELL CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 12, 2026 12:06 UTC
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New drug combo before kidney surgery shows promise in early trial
Disease control Not yet recruitingThis early-phase trial is testing whether giving two immunotherapy drugs (botensilimab and balstilimab) before surgery can help treat high-risk clear cell kidney cancer that hasn't spread. About 16 adults will receive the drugs before having their kidney tumor removed. The main g…
Matched conditions: STAGE IV RENAL CELL CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 08, 2026 13:13 UTC
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Gut bacteria boosts immunotherapy to fight kidney cancer recurrence?
Disease control Not yet recruitingThis phase 2 trial tests whether adding a live bacteria product called CBM588 to the standard immunotherapy drug pembrolizumab can help prevent kidney cancer from coming back after surgery. About 62 adults with high-risk kidney cancer will receive either pembrolizumab alone or pe…
Matched conditions: STAGE IV RENAL CELL CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 01, 2026 17:56 UTC