STAGE IV PROSTATE CANCER AJCC V8

This study is for men with prostate cancer that has spread to other parts of the body. It compares standard drug therapy alone versus standard drug therapy plus either surgery to remove the prostate or radiation to the prostate. The goal is to see if adding local treatment helps …

This study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach for prostate cancer that has come back after surgery or spread to a few spots. About 118 men will receive either SBRT or hypofractionated radiotherapy. …

This study tests whether giving a drug called abemaciclib before a targeted radiation therapy (177Lu-PSMA-617) can make the radiation work better for men with advanced prostate cancer that has stopped responding to other treatments. About 30 participants will receive the combinat…

This study is testing a daily pill called talazoparib in people with advanced solid tumors (like breast, prostate, ovarian, or pancreatic cancer) that have specific DNA repair gene mutations. The drug works by blocking a protein that helps cancer cells fix their DNA, causing them…

This study tests two drugs, cabozantinib and atezolizumab, in 33 men with a type of advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see if the combination can stop or shrink tumors. Participants must have non-measurable disease o…

This study tests whether adding the drug talazoparib to standard hormone therapy can better control advanced prostate cancer that still responds to hormone treatment. About 70 men with cancer that has spread will receive the combination. The goal is to see if this approach lowers…

This study tests a radioactive drug called lutetium Lu 177 dotatate in 30 people with a rare and aggressive form of prostate cancer that has spread. The drug seeks out and delivers radiation directly to cancer cells that have certain markers. The goal is to see if it can shrink t…

This study tests whether a short course of hormone therapy (relugolix) can make PSMA PET/CT scans better at finding prostate cancer that has spread to lymph nodes. About 30 men with high-risk prostate cancer will get the hormone drug for 5, 10, or 15 days before their scan. The g…

This study looks at whether giving cancer therapy at home instead of in a clinic is safe and improves the experience for Black men with advanced prostate cancer. About 38 participants will receive treatment both at home and in the clinic, then rate their satisfaction and report s…

This study compares the side effects of two standard treatments for advanced prostate cancer: abiraterone plus prednisone versus darolutamide alone. Researchers want to see which drug causes fewer severe side effects in 75 adult patients. The goal is to help doctors choose the tr…

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to their bones. About 40 adults with advanced cancers like prostate, kidney, or melanoma will be enrolled. The goa…

This study tests if using bright white light therapy can reduce fatigue and improve mood in men with advanced prostate cancer who are receiving hormone therapy (ADT) combined with other treatments. About 210 men will either start light therapy right away or after a delay. The goa…

This study looks at whether a network of peer genetic coaches can help African American men with metastatic prostate cancer overcome barriers to genetic testing. The coaches will provide support and navigation to increase awareness and access. The study involves 30 participants a…

This study looks at whether having a trained peer navigator—someone who guides patients through the process—helps African American men with advanced prostate cancer better understand and complete genetic testing. Genetic testing is important for treatment decisions, but many pati…

This study looks at how common low vitamin D levels are in Black/African American men with prostate cancer, and whether vitamin D supplements can improve immune function. Researchers will measure vitamin D levels and immune responses in 220 participants. The goal is to understand…