STAGE III BREAST CANCER AJCC V7

This early-phase trial tests an endoxifen gel applied to the breast in 32 women scheduled for mastectomy. The goal is to find the safest dose and check for skin reactions. Endoxifen may help control or lower breast cancer risk, but this study focuses on side effects and drug leve…

This study tests the drug pembrolizumab in people with advanced solid tumors that have certain gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. About 21 adults with metastatic or recurrent cancer took part. Pembrolizu…

This study tests whether a newer drug, Z-Endoxifen, works better than the standard tamoxifen for postmenopausal women with advanced ER+/HER2- breast cancer. About 81 participants will receive one of the two hormone therapies to see which delays cancer growth longer. The goal is t…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced solid tumors that have spread or can't be removed by surgery. The cancers include certain types of breast, lung, and pancreatic cancer. The goal is to see if the drug combo can shrink tum…

This study tests whether adding the immunotherapy drug pembrolizumab after standard chemotherapy helps prevent breast cancer from returning in people with triple-negative breast cancer. About 1,155 participants who still had cancer after chemo will receive either pembrolizumab or…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy before surgery helps shrink tumors more than chemo alone in people with stage II-III triple negative breast cancer. About 67 participants will receive either chemo alone or chemo plus ate…

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, social support, and reducing exposure to environmental toxins—can improve outcomes for women with stage II or III breast cancer who are receiving radiation the…

This study looks at whether a type of acupuncture that uses mild electrical pulses can help reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women who have had pain for at least 3 months after surgery will be randomly assigned to r…