Immunotherapy drug shows promise for hard-to-treat cancers with genetic flaws

NCT ID NCT03428802

First seen Apr 09, 2026 · Last updated Jun 14, 2026 · Updated 12 times

Summary

This study tests the drug pembrolizumab in people with advanced solid tumors that have certain gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. About 21 adults with metastatic or recurrent cancer took part. Pembrolizumab is an immunotherapy that helps the immune system attack cancer cells.

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Contacts and locations

Locations

  • Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

    New York, New York, 10016, United States

  • Rutgers Cancer Institute of New Jersey

    New Brunswick, New Jersey, 08903, United States

Conditions

Explore the condition pages connected to this study.