STAGE IIIA BREAST CANCER AJCC V7

This early-phase trial tests an endoxifen gel applied to the breast in 32 women scheduled for mastectomy. The goal is to find the safest dose and check for skin reactions. Endoxifen may help control or lower breast cancer risk, but this study focuses on side effects and drug leve…

This study tests the drug pembrolizumab in people with advanced solid tumors that have certain gene mutations (BRCA1, BRCA2, POLE, or POLD1). The goal is to see if the drug can shrink or control the cancer. About 21 adults with metastatic or recurrent cancer took part. Pembrolizu…

This study tests whether a newer drug, Z-Endoxifen, works better than the standard tamoxifen for postmenopausal women with advanced ER+/HER2- breast cancer. About 81 participants will receive one of the two hormone therapies to see which delays cancer growth longer. The goal is t…

This study tests a combination of two drugs, cediranib and olaparib, in people with advanced solid tumors that have spread or can't be removed by surgery. The cancers include certain types of breast, lung, and pancreatic cancer. The goal is to see if the drug combo can shrink tum…

This study looks at whether a type of acupuncture that uses mild electrical pulses can help reduce chronic pain in women who have finished treatment for early-stage breast cancer. About 111 women who have had pain for at least 3 months after surgery will be randomly assigned to r…

This study compares a 3-week radiation schedule to the standard 5-week schedule for women with invasive breast cancer who need radiation to the lymph nodes near the breast. The goal is to see if the shorter treatment works just as well to prevent cancer from coming back, while al…