SKIN AGING

This study tested a medical device called ULTRACOL, a dissolvable implant placed under the skin, to see if it can safely improve wrinkles and other skin contour problems. 23 adults with facial wrinkles or skin aging took part. The main goal was to measure changes in wrinkle sever…

This study tested a gel-like implant (Algeness) to improve the look of wrinkles and other skin contour problems. 40 adults aged 30-65 with age-related skin changes took part. The main goal was to see if the implant reduced wrinkle severity on a standard scale. The study is comple…

This study tested whether a daily dietary supplement called NatureU BeautyU Caps could improve signs of skin aging in adult women. Thirty-one women aged 36 to 56 took one capsule daily for 56 days. Researchers measured changes in crow's-feet wrinkles and skin hydration using spec…

This completed study tested an injectable gel made of hyaluronic acid and lecithin in 36 women with thin, dry, and sagging facial skin. The goal was to see if the gel safely improves skin thickness and appearance. Participants received three injections over several visits, and sk…

This study tested whether focused ultrasound can safely improve mild to moderate facial skin looseness (laxity) in adults. Nineteen participants received a single treatment session on both sides of their face, with different hand-pieces used on each side for comparison. Researche…

This study tested a new microneedling device on 33 adults with mild to moderate facial wrinkles. The device uses tiny needles to create small injuries in the skin, which may help reduce wrinkles and improve skin appearance. Participants received two treatments and were followed f…

This study tested whether a retinaldehyde cream (a form of vitamin A) can improve signs of aging skin in women aged 30 to 60. Fifty-six women applied a stronger cream (0.1%) to one side of their face and a weaker cream (0.05%) to the other side every evening for 24 weeks. Researc…

This study tested a serum and cream containing four active ingredients (GABA, DMAE, cysteamine, and bakuchiol) to see if they could improve skin brightness and reduce wrinkles. 44 healthy women aged 30-50 used the products or a placebo for 8 weeks. Researchers measured changes in…

This completed Phase 4 trial tested whether applying exosomes (tiny particles from cells) to the face with a microneedling device can reduce signs of skin aging. Thirty men and women over 50 with wrinkles and other aging signs received three treatments, each four weeks apart. Res…

This study tested whether a single session of radiofrequency treatment with continuous water cooling could improve jawline contour and facial volume in 22 women aged 38-50. Participants received one treatment and were followed for 8 weeks. The goal was to see if the device could …

This study tested whether a special cream can reduce redness, swelling, and pain after laser skin treatment. Eleven adults each had four small areas treated with laser, then different creams were applied. Participants rated their symptoms daily for two weeks. The goal was to find…

This completed Phase 1 trial tested whether injecting a botulinum toxin (prabotulinumtoxinA-xvfs, also known as Jeuveau) into the forehead can improve facial skin quality, fine wrinkles, and texture. Twenty women with mild to moderate wrinkles received the treatment on one side o…

This study tested a light-emitting diode (LED) face and neck mask in 38 women aged 25–55 with signs of skin aging and sun damage. Participants used the mask daily for 10 minutes over 12 weeks. Researchers checked photos and surveys to see if the mask improved wrinkles, pigmentati…

This study checked if skin hydration levels are linked to visible signs of facial aging. Thirty women aged 30 to 60 had their skin moisture measured at seven spots on their face using a special device. Photos were then scored by an expert to see if drier skin matched more aging. …

This study looked at 100 women at different stages of menopause to see how skin aging in sun-exposed and non-exposed areas relates to hot flashes, mood, and sleep. Researchers measured skin wrinkles, color, elasticity, and moisture, and tracked sleep and symptoms at home for 30 d…

This completed pilot study tested whether a fully digital, at-home approach can work for skin health research. Over 1000 adults aged 18 to 65 took self-portraits, answered lifestyle questions, and some collected skin microbiome samples. The goal was to see how efficiently people …