SICKLE CELL ANEMIA
Clinical trials for SICKLE CELL ANEMIA explained in plain language.
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New stem cell transplant could help sickle cell patients without a perfect donor match
Disease control OngoingThis study tests a stem cell transplant using cells from a half-matched family donor, combined with low-dose radiation and drugs to prevent rejection, for adults with severe sickle cell disease or beta-thalassemia. The goal is to see if this gentler approach can replace the disea…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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CRISPR gene therapy: a Long-Term safety check for blood disease patients
Disease control ENROLLING_BY_INVITATIONThis study follows 160 children and adults with beta-thalassemia or sickle cell disease who received a one-time treatment of their own CRISPR-edited stem cells (CTX001). The goal is to monitor long-term safety, including any new cancers or blood disorders, and to see how well the…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE3 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New antibody could boost stem cell transplant success for blood disorders
Disease control OngoingThis study tests whether adding an antibody called briquilimab (JSP191) to a standard stem cell transplant can help more donor cells take root in people with sickle cell disease or beta-thalassemia. About 40 patients aged 13 and older will receive the antibody along with low-dose…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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New study tests mindfulness therapy for sleep in sickle cell disease
Symptom relief TerminatedThis study looks at whether acceptance and commitment therapy (ACT) can improve sleep for adults with sickle cell disease. Participants will have weekly video chats with a coach for 8 weeks and wear a wrist device to track sleep. The goal is to see if this approach is practical a…
Matched conditions: SICKLE CELL ANEMIA
Phase: NA • Sponsor: National Cancer Institute (NCI) • Aim: Symptom relief
Last updated Jun 27, 2026 07:58 UTC
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Tiny study probes Mitapivat's inner workings in sickle cell
Knowledge-focused OngoingThis observational study will examine how the drug mitapivat changes red blood cells in 6 people with sickle cell disease. Researchers will measure oxygen binding and cell survival markers from blood samples and muscle oxygen tests. The goal is to understand the drug's effects, n…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jul 02, 2026 03:00 UTC
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Hidden brain damage in young sickle cell patients: new study aims to find answers
Knowledge-focused OngoingThis study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia, especially in Nigeria where the disease is widespread. Researchers will use brain scans and blood tests to check for damage and identify risk factors like hi…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:19 UTC