SICKLE CELL ANEMIA
Clinical trials for SICKLE CELL ANEMIA explained in plain language.
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Could a new antibody make stem cell transplants a real cure for blood disorders?
⭐️ CURE ⭐️ OngoingThis study tests whether adding a new antibody drug (briquilimab, JSP191) to a standard stem cell transplant can help more people with sickle cell disease or beta-thalassemia achieve a full donor blood system, potentially curing their condition. About 40 participants aged 13 and …
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: ⭐️ CURE ⭐️
Last updated May 13, 2026 16:03 UTC
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New hope for sickle cell: half-matched transplant without chemo
Disease control OngoingThis study tests a stem cell transplant from a half-matched family donor for adults with severe sickle cell disease or beta-thalassemia. Instead of high-dose chemotherapy, it uses low-dose radiation and immune-suppressing drugs to prepare the body. The goal is to see if this gent…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE1, PHASE2 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated May 14, 2026 12:05 UTC
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CRISPR gene therapy: a Long-Term look at safety for blood disease patients
Disease control ENROLLING_BY_INVITATIONThis study follows 160 children and adults with beta-thalassemia or sickle cell disease who received a one-time treatment of their own CRISPR-edited stem cells (CTX001). Researchers will monitor participants for years to check for side effects, new cancers, and how well the thera…
Matched conditions: SICKLE CELL ANEMIA
Phase: PHASE3 • Sponsor: Vertex Pharmaceuticals Incorporated • Aim: Disease control
Last updated May 13, 2026 16:00 UTC
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New study tests mindfulness therapy for sickle cell sleep troubles
Symptom relief TerminatedThis study tests whether acceptance and commitment therapy (ACT), a type of talking therapy, can help adults with sickle cell disease who have trouble sleeping. Participants will have weekly video chats with a coach for 8 weeks and wear a wrist device to track sleep. The goal is …
Matched conditions: SICKLE CELL ANEMIA
Phase: NA • Sponsor: National Cancer Institute (NCI) • Aim: Symptom relief
Last updated May 17, 2026 03:08 UTC
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Hidden brain damage in young sickle cell patients: a ticking clock?
Knowledge-focused OngoingThis study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia in northern Nigeria. Researchers will use brain scans and blood flow tests to find hidden damage and check for risk factors like high blood pressure. The goal…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated May 14, 2026 12:03 UTC
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Sickle cell drug study looks under the microscope at red blood cells
Knowledge-focused OngoingThis observational study looks at how the drug mitapivat changes red blood cells in people with sickle cell disease. Researchers will measure how well the cells carry oxygen and how long they survive. The study involves about 6 people already enrolled in a larger trial, with extr…
Matched conditions: SICKLE CELL ANEMIA
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated May 12, 2026 13:39 UTC