SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Clinical trials for SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS explained in plain language.
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MS trial withdrawn before it began: CAR T-Cell hope on hold
Disease control TerminatedThis study aimed to test a new treatment called CABA-201, a CAR T-cell therapy made from a patient's own immune cells, for people with multiple sclerosis (MS). The goal was to see if it was safe and could control the disease by targeting and resetting the immune system. However, …
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE1, PHASE2 • Sponsor: Cabaletta Bio • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Cheaper MS drug could match pricey standard in major trial
Disease control OngoingThis phase 3 trial tests whether rituximab, a cheaper drug, works as well as ocrelizumab for active multiple sclerosis. About 600 adults with relapsing or progressive MS will receive one of the two drugs. The main goal is to see if rituximab can prevent new brain lesions as effec…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE3 • Sponsor: Rigshospitalet, Denmark • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Could a cancer drug slow MS progression? new trial halted midway
Disease control TerminatedThis phase 3 trial tests whether the oral drug masitinib can slow disability worsening in people with progressive multiple sclerosis who do not have relapses. About 800 participants will receive either masitinib or a placebo for 96 weeks. The main goal is to see if masitinib dela…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE3 • Sponsor: AB Science • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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MS drug holiday for Over-50s: safe or risky?
Disease control OngoingThis study looks at whether people over 50 with a stable, inactive form of secondary progressive multiple sclerosis can stop taking their disease-modifying drugs without getting worse. Researchers will track 250 participants for 2 years to see if stopping treatment leads to more …
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE3 • Sponsor: Rennes University Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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New MS drug tolebrutinib tested for Long-Term safety in 2,500 patients
Disease control OngoingThis study tests the long-term safety of the drug tolebrutinib in 2,500 adults with relapsing or progressive multiple sclerosis. Participants previously took part in earlier trials and will continue taking tolebrutinib or a placebo for up to several years. The goal is to see if t…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE3 • Sponsor: Sanofi • Aim: Disease control
Last updated Jun 27, 2026 09:05 UTC
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Stem cells from amniotic fluid tested for progressive MS – but trial pulled
Disease control TerminatedThis study aimed to test whether stem cells from amniotic fluid, injected into the spinal fluid, could safely help people with progressive multiple sclerosis (MS). The trial was designed for adults aged 18–60 with primary or secondary progressive MS. However, the study was withdr…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: PHASE1, PHASE2 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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New hope for MS patients: drug access program opens for those with no alternatives
Disease control NO_LONGER_AVAILABLEThis program provides access to siponimod, a medication that helps control active secondary progressive multiple sclerosis (SPMS). It is for adult patients who have no satisfactory treatment options. Doctors can request the drug for eligible patients through a compassionate use p…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Can a better diet ease MS symptoms? new study tests diet quality and calorie cutting
Symptom relief OngoingThis study looks at whether improving diet quality and reducing calories can help physical function, thinking, pain, fatigue, mood, and anxiety in 100 adults with relapsing-remitting or secondary progressive multiple sclerosis. Participants receive prepared meals and behavioral s…
Matched conditions: SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS
Phase: NA • Sponsor: University of Alabama at Birmingham • Aim: Symptom relief
Last updated Jun 27, 2026 12:03 UTC