RESPIRATORY INSUFFICIENCY

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests whether dexmedetomidine, a sedative that keeps patients more awake and has fewer side effects, can improve survival and reduce confusion in older adults (65+) on breathing machines in the ICU. Researchers will compare it to a placebo (salt water) in 300 patients …

This study tests whether using a high-flow nasal cannula (a device that delivers warm, moist oxygen at high speeds) for 24 hours after major abdominal surgery can prevent lung complications like pneumonia or collapsed lungs. Researchers will compare this to standard oxygen therap…

This study tests a redesigned non-invasive ventilation mask that may help people with respiratory insufficiency breathe more easily. Sixty adults who are stable on NIV will wear their usual mask for one hour and then the new mask for one hour. Researchers will measure breathing r…

This study tests a procedure that freezes the nerves around broken ribs to see if it reduces pain and helps people breathe better. About 30 adults with at least two broken ribs and severe pain will either get the freezing treatment or standard pain medicine. Researchers will trac…

This study will test whether using higher or standard pressure on a ventilator during surgery helps patients breathe better after waking up. About 360 adults having planned non-chest, non-heart surgery will be randomly assigned to one of two pressure levels. The main goal is to s…

This study checks if a Turkish version of a questionnaire called S3-NIV is reliable and accurate for people with chronic breathing failure who use a home breathing machine. Researchers will ask 120 stable patients to fill out the questionnaire to see how well it measures their di…

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study looks at a new way to close the belly wall during large hernia surgery to prevent breathing problems right after the operation. Doctors will use standard breathing measurements during surgery to decide the best closure method. The study will include 50 adults who are a…

This study looks at how different levels of positive end-expiratory pressure (PEEP) on a ventilator affect the diaphragm and lungs in ICU patients with respiratory failure. Twenty-five adults on pressure support ventilation will each receive low, medium, and high PEEP for short p…