RECURRENT BREAST CARCINOMA

This early-stage trial tests a personalized vaccine made from a patient's own tumor, given alone or with drugs that boost the immune system (pembrolizumab or ipilimumab). The goal is to see if the vaccine is safe and can help the immune system fight triple negative breast cancer …

This early-stage trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors. Ab…

This study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…

This study tests a new treatment for women with recurrent breast cancer who had previous breast-conserving therapy. It uses a single, targeted dose of radiation before repeat surgery to shrink the tumor and possibly reduce side effects and improve cosmetic results. The trial will…

This study looks at whether women whose breast cancer has returned after previous radiation can safely have breast-conserving surgery and another round of radiation instead of removing the whole breast. About 60 participants will be followed for up to 5 years to check for side ef…

This study collects tumor samples and medical information from 2000 adults with breast cancer that has spread or come back. The goal is to create a resource that helps researchers learn how the disease changes and responds to treatments. Participants provide samples and data but …

This study watches people with HER2+ breast cancer that has spread, who are getting trastuzumab-based treatment. The main goal is to see how often heart problems happen, especially in those also taking beta blockers or other heart medications. A smaller part of the study tests if…