PROSTATE CANCER METASTATIC DISEASE

This study tests an experimental oral drug called HLD-0915 in men with metastatic prostate cancer that has worsened after other treatments. The trial has two phases: Phase 1 checks safety and the best dose, while Phase 2 looks at how well it controls the cancer. About 190 men wil…

This study tests whether adding targeted local treatments (like radiation or surgery) to standard hormone therapy can slow disease progression in men with metastatic hormone-sensitive prostate cancer. Doctors will use PSMA PET/CT scans to find remaining active tumors after initia…

This study looks at whether a low-calorie, anti-inflammatory diet combined with walking can reduce heart disease risk factors in men with advanced prostate cancer who are on hormone therapy (ADT). Researchers will compare results between African American and non-Hispanic white me…

This study tests a new imaging method called FAPI PET/MRI to see if it can find and track prostate cancer that has spread better than current scans. About 30 adults with prostate cancer will get two research scans. The goal is to improve how doctors detect and monitor the disease…

This study tests a special dye that makes prostate cancer cells glow during surgery. About 22 men with aggressive prostate cancer will receive the dye before their prostate removal surgery. Surgeons will use a special camera to see the glowing cancer, helping them remove more of …

This study is testing whether adding a PSMA PET scan to the usual MRI can better detect prostate cancer that has come back after focal therapy. Focal therapy treats only the cancerous part of the prostate, but cancer can sometimes return. The PSMA PET scan uses a radioactive dye …

This study tests a drug called fezolinetant to see if it can reduce hot flashes in men with prostate cancer who are on hormone therapy (androgen deprivation therapy). About 60 men will take either the drug or a placebo daily for 4 weeks. Researchers will track hot flash frequency…

This study is for people with advanced prostate cancer that has spread to bones or lymph nodes and is no longer responding to standard treatments. Researchers want to find the largest total volume of cancer spots that can be safely treated with a precise type of radiation called …

This study aims to improve treatment for aggressive prostate cancer by growing 3D mini-tumors from patient samples in the lab. Researchers will compare two techniques to see which better predicts how a patient's cancer will respond to radiation or drugs. The goal is to help docto…

This study looks at whether a special type of scan (LuPSMA-SPECT/CT) can tell doctors early if a targeted radiation therapy is working in men with advanced prostate cancer that no longer responds to hormone therapy. About 130 participants will be followed to see if changes on the…