PREVENTION

This study tests whether a cold plasma treatment applied during groin surgery can prevent wound healing problems in people with peripheral artery disease who are at high risk for complications. About 214 participants will receive either the real plasma or a placebo device during …

This study tests whether taking a daily antiviral pill (acyclovir) can prevent herpes simplex outbreaks in people with autoimmune rheumatic diseases like lupus or rheumatoid arthritis. About 62 participants will receive either the drug or a placebo for 12 months, then be monitore…

This study tests a new, larger packet of a nutritious supplement (SQ-LNS) that lasts 7 days, compared to the current daily packets. Researchers want to see if families use the weekly packet correctly and like it. The goal is to prevent malnutrition in children aged 6-24 months in…

This study will test a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risk. About 200,000 patients will be involved, and researchers will compare …

This study tests whether a smartphone app called 'Better Pregnancy,' powered by artificial intelligence, can help prevent gestational diabetes in pregnant women who are at high risk. About 400 women will either use the app plus receive standard prenatal care, or receive standard …

This study looks at ways to help more Black women get PrEP, a daily pill that prevents HIV. Researchers will work with Planned Parenthood clinics in Illinois to find and support women who are at higher risk. About 250 women will take part, and the goal is to see if new strategies…

This study aims to improve an existing youth violence prevention program by adding content that directly addresses firearm-related risks, such as gun carrying and safe storage. Researchers will work with 45 teens aged 13-17 who are at high risk for firearm injury, along with thei…

This study tests two smartphone app programs designed to prevent anxiety and depression in adults who do not currently have these conditions. About 2,600 participants from Spain and Chile will use the app for one year. The goal is to see if personalized tips and tracking can lowe…

This study tests a program designed to improve mental health and well-being in children aged 8-10 and their parents. About 15,200 families in four European countries will take part. Children attend a mental health day, and parents receive training or a guidebook. Researchers will…

This study tests a new approach to delivering the SafeCare program, which helps parents prevent child maltreatment. Researchers will work with 12 home visiting providers and 40 caregivers to see if a mix of in-person and virtual sessions can reach more families and improve parent…

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This study looks at a program called ezParent that combines online training with group sessions to help parents of children aged 2 to 5. About 516 parents will take surveys to see if the program improves parenting skills and child behavior. The goal is to make support more access…