PREVENTION

This study tests whether a 16-week family-based psychosocial intervention can reduce persistent and distressing psychotic-like experiences in children and young adults who have a family history of schizophrenia spectrum disorders (SSD). Participants and their caregivers will atte…

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This trial tests whether giving patients personalized prevention tips in the emergency department helps them follow through on recommended health measures, like cancer screenings and vaccines. About 658 adults visiting two ERs in France receive either tailored advice based on the…

This trial tests whether taking a single dose of the antibiotic doxycycline within 24 hours of condomless sex can prevent bacterial sexually transmitted infections (STIs) like chlamydia, gonorrhea, and syphilis in women aged 18–35 at increased risk. Participants are randomly assi…

This study tests a technology-enhanced version of SafeCare, a home visiting program that helps parents keep children safe. Researchers will work with 12 providers and 40 caregivers to see if a mix of in-person and virtual sessions can reach more families and improve parenting ski…

This study tests whether a single session of Acceptance and Commitment Therapy (ACT) can help internally displaced adults manage stress and prevent substance use. Researchers will enroll 144 people who have been displaced by conflict and have used at least one substance (other th…

This study aims to improve an existing violence prevention program for high-risk youth by adding content that directly addresses firearm safety. Researchers will work with about 45 teens aged 13-17 to develop and test new materials. The goal is to reduce the risk of intentional f…

This study in Ethiopia tests whether a new 7-day package of a nutritional supplement (SQ-LNS) works as well as the usual daily packets for preventing malnutrition in children aged 6-24 months. Researchers will compare how well families stick to using each package type over 8 week…

This study tests whether a smartphone app called "Better Pregnancy" can help prevent gestational diabetes in pregnant women at high risk. About 400 women will either use the app plus get standard prenatal care, or receive standard care alone. The app provides personalized diet, a…

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study looks at ways to help Black women get PrEP, a daily pill that prevents HIV. Researchers will try special strategies at family planning clinics to see if more women start and stay on PrEP. About 250 women with a recent STI will take part.

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…